Lara Crow

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy

Jonathan J. Havel, Diego Chowell & Timothy A. Chan

Latest Reviews

  • Perspective |

    The existence of extrachromosomal DNA (ecDNA) in cancer was first described decades ago, but recent reports of oncogene amplification on ecDNA have reinvigorated interest in this field. This Perspectives article discusses the potential implications of oncogene amplification on ecDNA in cancer.

    • Roel G. W. Verhaak
    • , Vineet Bafna
    •  & Paul S. Mischel
  • Review Article |

    In addition to cancer cell-intrinsic effects, tumour growth can be regulated by cellular and molecular cues from the local tissue environment. This Review discusses how differences in cellular components and composition between tissue sites may influence the antitumour immune response, with potential implications for the design of therapeutic strategies.

    • Hélène Salmon
    • , Romain Remark
    • , Sacha Gnjatic
    •  & Miriam Merad
  • Review Article |

    Inflammasome signalling in myeloid cells protects against microbial infections. Aberrant inflammasome signalling promotes chronic inflammation, which contributes to tumorigenesis. This Review presents an overview of the diverging roles of inflammasomes in cancer and discusses its targeting potential in anticancer therapy.

    • Rajendra Karki
    •  & Thirumala-Devi Kanneganti
  • Progress |

    In this Progress article, Wu, Jusiak and Lu discuss how synthetic biology-based design principles can be applied to living cells to overcome key challenges in current cancer therapy and generate more robust, specific and effective gene circuit therapies.

    • Ming-Ru Wu
    • , Barbara Jusiak
    •  & Timothy K. Lu
  • Review Article |

    This Review discusses recent work demonstrating that immune checkpoint inhibitor efficacy is affected by a combination of factors involving tumour genomics, host germline genetics, programmed cell death 1 ligand 1 (PDL1) levels and other features of the tumour microenvironment, as well as the gut microbiome.

    • Jonathan J. Havel
    • , Diego Chowell
    •  & Timothy A. Chan
  • Review Article |

    In this Review, Jones et al. present the evidence that epigenetic therapies can induce the expression of endogenous retroviruses and cancer–testis antigens normally silenced by DNA methylation in most somatic cells. As a consequence, a state of viral mimicry is evoked in cancer cells, leading to an innate immune response. Understanding this process has implications for combination therapy with epigenetic drugs and immunotherapies to improve clinical outcomes for patients with cancer.

    • Peter A. Jones
    • , Hitoshi Ohtani
    • , Ankur Chakravarthy
    •  & Daniel D. De Carvalho

News & Comment

  • Research Highlight |

    Singhal et al. characterized tumour-infiltrating monocyte and macrophage lineage cells in patients with early stage lung cancer and found that, contrary to data in mouse models, the function of these cells might not be primarily immunosuppressive.

    • Maria Giuseppina Baratta
  • Research Highlight |

    Miller, Sen et al. show that exhausted T cells in tumours contain distinct subpopulations, one of which is long-lived and persistent and, in response to immune checkpoint blockade, can give rise to short-lived cytotoxic T cells that exert tumour control.

    • Ulrike Harjes
  • Comment |

    In an effort to prevent bullying and harassment in the research sector, funding bodies have introduced policies to promote a positive research culture. Here, Sue Russell and Iain Foulkes comment on what this means for researchers.

    • Sue Russell
    •  & Iain Foulkes
  • Research Highlight |

    In a study published in Nature, Messal, Alt et al. report the use of a new imaging technique that has shed light on the morphology of developing tumours within pancreatic ducts.

    • Sarah Seton-Rogers
  • Research Highlight |

    Lee et al. show that in a mouse model of melanoma, tumour cells that spread to the draining lymph node adapt to the fatty acid-rich environment in the lymph node by activation of YAP signalling and fatty acid oxidation.

    • Ulrike Harjes
  • Research Highlight |

    Two independent studies have advanced our understanding of local microbiota immunomodulation and provided insight into how potential manipulation of microbial composition could transform treatment strategies for patients with cancer.

    • Anna Dart


The tumour microenvironment

Lara Crow

The tumour microenvironment

This Collection from Nature Reviews Cancer brings together some of our most recently published articles focused on understanding the role the tumour microenvironment plays in tumour progression as well as therapeutic responses and resistance.

Nature events Directory