Lara Crow

Clinical tumour sequencing for precision oncology: time for a universal strategy

Latest Reviews

  • Review Article |

    This Review discusses how cells with stem cell characteristics often serve as the tumour cell of origin, as they are preferentially primed for transformation. Furthermore, the activation of stem cell programmes can be crucial for promoting cancer progression and therapy resistance.

    • Nikki K. Lytle
    • , Alison G. Barber
    •  & Tannishtha Reya
  • Review Article |

    This Review discusses the reprogramming of the urea cycle, the main metabolic liver pathway for nitrogen disposal, in cancer cells. The authors provide insight into the metabolic advantages and therapeutic opportunities stemming from urea cycle enzyme perturbations in cancer.

    • Rom Keshet
    • , Peter Szlosarek
    • , Arkaitz Carracedo
    •  & Ayelet Erez
  • Review Article |

    Cancer is ubiquitous in wildlife and is an increasing concern for endangered species. This Review discusses the impact of cancer on animal species and highlights how studying these effects could reveal shared mechanisms of cancer predisposition between animals and humans.

    • Patricia A. Pesavento
    • , Dalen Agnew
    • , Michael K. Keel
    •  & Kevin D. Woolard
  • Review Article |

    This Review discusses nutrient scavenging, a process by which cancer cells use macromolecules from their environment to fuel cell metabolism and growth even when nutrients are limiting.

    • Brendan T. Finicle
    • , Vaishali Jayashankar
    •  & Aimee L. Edinger
  • Review Article |

    In this Review, Di Virgilio et al. describe how extracellular ATP and P2 purinergic signalling can shape the tumour microenvironment to both promote and restrain tumour progression and outline the opportunities to harness nucleotide receptor signalling as an anticancer strategy.

    • Francesco Di Virgilio
    • , Alba Clara Sarti
    • , Simonetta Falzoni
    • , Elena De Marchi
    •  & Elena Adinolfi

News & Comment

  • Research Highlight |

    Lee, Singh et al. find that cancer-specific intronic polyadenylation events occur frequently in tumour suppressor genes in chronic lymphocytic leukaemia (CLL) and generate truncated proteins that could act as CLL drivers.

    • Sarah Seton-Rogers
  • Research Highlight |

    Lee, Adler et al. show that urea cycle dysregulation is common in cancer and leads to a purine to pyrimidine mutational bias that is associated with a better response to immune checkpoint inhibitors.

    • Sarah Seton-Rogers
  • Research Highlight |

    Yao et al. have established that acute lymphoblastic leukaemia cells bypass the need to metastasize via the circulation to the CNS and instead use a direct route migrating along the vascular channels that bridge the bone marrow to the meninges in an α6 integrin-dependent manner.

    • Anna Dart
  • Research Highlight |

    A recent study, published in Nature, identifies the methylcytosine dioxygenase 2 (TET2) as an epigenetic modifier that is regulated in response to glucose availability and mechanistically links higher cancer susceptibility in patients with diabetes to high blood glucose levels.

    • Ulrike Harjes
  • Research Highlight |

    PI3K inhibition in solid cancers driven by PI3K catalytic subunit-α has shown limited clinical benefit. This might be due to activation of a glucose–insulin feedback loop, which can be interrupted by dietary or pharmaceutical approaches, thereby improving therapy outcome.

    • Ulrike Harjes

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