Lara Crow

A model for RAS mutation patterns in cancers: finding the sweet spot

Siqi Li, Allan Balmain & Christopher M. Counter

Latest Reviews

  • Review Article |

    This Review discusses causal germline variants in prostate cancer identified through genome-wide association studies (GWAS) and post-GWAS analyses. The latter are vital to identify causal variants and molecular mechanisms by which these variants promote prostate tumorigenesis, with potential clinical applications.

    • Samaneh Farashi
    • , Thomas Kryza
    • , Judith Clements
    •  & Jyotsna Batra
  • Review Article |

    In this Review, Altorki et al. discuss how the tumour-reprogrammed lung microenvironment can contribute to primary lung tumour progression as well as lung metastasis from extrapulmonary neoplasms by promoting inflammation, angiogenesis, immune modulation and therapeutic responses.

    • Nasser K. Altorki
    • , Geoffrey J. Markowitz
    • , Dingcheng Gao
    • , Jeffrey L. Port
    • , Ashish Saxena
    • , Brendon Stiles
    • , Timothy McGraw
    •  & Vivek Mittal
  • Review Article |

    This Review discusses the evidence that whole-genome duplication as a consequence of cytokinesis failure can contribute to tumorigenesis.

    • Susanne M. A. Lens
    •  & René H. Medema
  • Perspective |

    This Opinion argues that understanding the interactions between cells that occur in tumours requires concepts from evolutionary game theory. Game theory can provide insights into the stability of cooperation among cells in a tumour and how this might be used therapeutically.

    • Marco Archetti
    •  & Kenneth J. Pienta
  • Review Article |

    This Review discusses the interdependencies of mTOR signalling and metabolism pathways in cancer and how metabolic reprogramming in response to changes in mTOR signalling and vice versa can sustain tumorigenicity. The authors highlight therapeutic opportunities when targeting metabolism and mTOR.

    • Dirk Mossmann
    • , Sujin Park
    •  & Michael N. Hall
  • Perspective |

    This Opinion describes cell-in-cell processes in cancer, providing insight into their functional purpose in tumour tissue. Entosis is a unique process in which cancer cells are actively invaded by other cells, conferring them a competitive advantage that may drive cancer evolution.

    • Stefano Fais
    •  & Michael Overholtzer

News & Comment

  • Research Highlight |

    Two studies published in Cell have characterized the inhibitory immune receptor NKG2A expressed on cytotoxic lymphocytes, such as natural killer cells and CD8+ T cells, as a novel checkpoint for cancer immunotherapy.

    • Anna Dart
  • Research Highlight |

    New findings published in Nature Medicine highlight a role for the anti-CTLA4 antibody ipilimumab when combined with radiotherapy in treating metastatic NSCLC.

    • Jordan Hindson
  • Editorial |

    Cancer research and Nature Reviews Cancer have both experienced many highs and lows in 2018, and we look forward to what 2019 has in store.

    • Sarah Seton-Rogers
  • Research Highlight |

    Assi et al. have generated multi-omics data on leukaemic blasts from acute myeloid leukaemia (AML) patients with defined genetic alterations. These data provide a comprehensive overview of the specific transcriptional and signalling networks in certain AML subtypes.

    • Katharine H. Wrighton
  • Research Highlight |

    Lane et al. have shown that interferon-γ (IFNγ)-mediated activation of the lymphatic vasculature, as a non-haematopoietic component of the tumour stroma, serves to limit local CD8+ T cell accumulation in melanoma in mice as a mechanism of immune suppression.

    • Anna Dart
  • Research Highlight |

    Wang et al. demonstrate that increased flux of calcium derived from osteogenic cells into cancer cells promotes early-stage bone colonization. Calcium signalling in cancer cells can be targeted by arsenic trioxide, thereby reducing bone metastasis progression.

    • Urike Harjes

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