Volume 17

  • No. 6 June 2022

    Characterizing cell-type-specific chromatin landscapes

    ATAC-seq profiles the gene regulatory ‘landscape’ of a cell. Promoters, enhancers and other putative gene regulatory elements are identified as peaks in the data and these signals are highly cell-type-specific. Here, the skylines of Paris, San Francisco, New York City and Shanghai are depicted in the style of cell-type-specific ATAC-seq peaks.

    See Grandi et al.

  • No. 5 May 2022

    Hair-bearing skin organoids

    The image displays a human-stem-cell-derived skin organoid with radially growing hair follicles (green) and nerves (red/yellow). This particular organoid was grown from a genetically modified stem cell line where the Desmoplakin gene/protein is tagged with a GFP. As a consequence, the numerous desmosomes (cell–cell junctions) in the epidermis of the organoid glow green. Neurons are labeled with an antibody for beta-III tubulin.

    See Lee et al.

  • No. 4 April 2022

    Wireless active optogenetic device with real-time stimulation control

    The layered schematics of a wireless optogenetic device capable of full subdermal implantation over the skull with real-time control over optical modulation on neural activities. Application of such devices in live rodent models enables profound behavior studies that explore the underlying neural principles behind outcome behaviors.

    See Yang et al.

  • No. 3 March 2022

    Human breast tissue stained with FLARE

    Formalin-fixed paraffin-embedded human breast tissue that was rapidly stained by FLARE (fluorescent labeling of abundant reactive entities), enabling informative visualization analogous to classic histology stains and holding the potential to revolutionize the clinical practice of examining tissue samples.

    See Lee et al.

  • No. 2 February 2022

    Multiplexed imaging of diverse human tissues

    Rainbow collage of IBEX images from nine different human tissues, including the lymph node, thymus, spleen, jejunum, kidney, liver, skin and heart. Individual images display unique cell types and anatomical structures defined by a single protein biomarker. All protein biomarkers are targeted by commercially available antibodies and obtained by IBEX, an open-source multiplexed imaging method.

    See Radtke et al.

  • No. 1 January 2022

    Human neurons in culture

    Image of human striatal organoids that are derived from pluripotent stem cells in vitro and can be integrated with cortical cells to form cortico-striatal assembloids.

    See Miura et al.