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Volume 17 Issue 10, October 2022

Fibroblast cell forming filopodia on nanopatterns

Scanning electron microscope image (pseudo-color) of a fibroblast cell forming filopodia along nanofibers functionalized by the integrin-binding peptide Arg–Gly–Asp (RGD). The nanopatterns are arrays of 20-nm-wide lines with 80-nm center-to-center distance in each line pair. Functionalization of ligands on titanium nanopatterns enables super-resolution fluorescence microscopy to study cell–ligand interactions at the molecular scale.

See Jain et al.

Image: Haogang Cai, New York University Grossman School of Medicine. Cover design: S. Harris


  • In this Perspective, the authors propose genetically engineered mouse models to further the understanding and use of a recently discovered tool, selective endogenous encapsidation for cellular delivery via virus-like particles, in gene delivery and gene therapy applications.

    • Channabasavaiah B. Gurumurthy
    • Rolen M. Quadros
    • Masato Ohtsuka


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