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Volume 16 Issue 6, June 2021

Tutorial for clearing and imaging tissue samples

A CLARITY-cleared Thy-1-YFP-H mouse brain imaged with a mesoSPIM (mesoscale selective plane illumination initiative) light-sheet microscope. The image shows a single plane out of a 3D stack covering the whole brain.

See Weiss et al.

Image: Fabian F. Voigt, University of Zurich. Sample courtesy of Daniel Kirschenbaum, University Hospital Zurich. Cover design: Tulsi Voralia.


  • Nature Protocols has traditionally published protocols for use in biological or biomedical research but has recently expanded its scope to include protocols for clinical practice.



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