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Volume 15 Issue 2, February 2020

Volume 15 Issue 2

E. colion an LP: the power of CRISPR–Cas-mediated genome editing

This hand-colored scanning electron micrograph shows E. coli living on a phonograph record. These cells were engineered to express molecular components of the CRISPR–Cas system, enabling the cell to write a permanent record of the RNAs within the cell into its own genome, where it is safely stored. Scientists can retrieve the record and reveal the bacterium’s transcriptional history.

See Tanna et al.

Image: © 2018 M. Oeggerli, supported by Pathology, University Hospital Basel, C-CINA, Biozentrum, University Basel; F. Schmidt, M. Cherepkova and R. J. Platt, Department of Biosystems Science and Engineering, ETH Zurich, Basel. Cover Design: Erin Dewalt

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