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Volume 15 Issue 1, January 2020

Reading and writing digital data in DNA.

To illustrate the capabilities of this protocol the first cover image and the first five articles published in Nature Protocols (Vol. 1, Issue 1, pp 1–29) were stored on 12,474 short DNA sequences and retrieved without error by next-generation sequencing.

See Meiser et al.

Image: Linda Meiser and Robert Grass. Cover Design: Erin Dewalt.

Volume 15 Issue 1

Protocol Extensions

  • In this Protocol Extension, the authors extend their original Protocol used to generate a genome-scale metabolic model for a single strain to enable multi-strain models to be made, which can be used to study pan-metabolic capabilities and strain-specific differences across a species.

    • Charles J. Norsigian
    • Xin Fang
    • Bernhard O. Palsson
    Protocol Extension


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