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Volume 14 Issue 2, February 2019

Volume 14 Issue 2

Systemic AAV vectors for targeted gene delivery

Multicolor labeling of cardiac muscle with systemic AAVs. Three fluorescent proteins (mTurquoise2, mNeonGreen, and mRuby2) were separately packaged into AAV-PHP.S and systemically codelivered to a wild-type mouse at 3.3 × 1011 vector genomes (vg) per virus (1 × 1012 vg total). Gene expression in the heart was evaluated 11 d later. Individual cardiomyocytes can be easily distinguished from one another.

See Challis et al.

Images taken from the protocol by Challis et al. doi: 10.1038/s41596-018-0097-3. Cover design by Erin Dewalt.

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