Volume 13 Issue 5, May 2018

Volume 13 Issue 5

The cover image depicts a two-dimensional cubic lattice that conceptually mimics a crystal lattice in protein crystals. A protein structure (galactoside O-acetyltransferase; PDB 5V0Z) is shown here in dark red, with possible metal-binding sites highlighted in yellow. The image related to the protocol by Handing et al. (doi:10.1038/nprot.2018.018) was designed by Kasia Handing, Heping Zheng and David Cooper. Cover design by Erin Dewalt.


Protocol Extension

  • Protocol Extension |

    This protocol describes production and bioinformatics analysis pipelines for E/L Repli-seq, an extension of the earlier Repli-chip protocol, allowing rapid genome-wide replication-timing analysis by next-generation sequencing.

    • Claire Marchal
    • , Takayo Sasaki
    • , Daniel Vera
    • , Korey Wilson
    • , Jiao Sima
    • , Juan Carlos Rivera-Mulia
    • , Claudia Trevilla-García
    • , Coralin Nogues
    • , Ebtesam Nafie
    •  & David M Gilbert