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This Perspective from Janet Jansson and colleagues reviews the development of microbiome analysis technologies over the last decade, and comments on the future potential of this fast-moving field.
This Perspective from Jay Shendure's lab reviews the past decade's development of multiplexed assays for variant effects, and also comments on the potential of these experiments for the functional interpretation of genetic variation.
Tissue engineering encompasses various scientific disciplines with the aim of revolutionizing our outlook on the future of research and medicine. In this Perspective, Robert Langer and Ali Khademhosseini discuss the advancing field of tissue engineering, featuring high-impact technologies over the past decade and their own future perspectives on the field.
CRISPR–Cas9 has truly democratized genome editing. In this Perspective, Jin-Soo Kim discusses CRISPR–Cas9 genome editing in the context of earlier innovations using meganucleases, ZFNs and TALENs, which paved the way for the ongoing CRISPR–Cas revolution.
iPSC technology has radically advanced our understanding of mammalian development. In this Perspective, Belmonte and Li discuss breakthroughs in iPSC technology over the past decade and share their predictions for the future of iPSCs in developmental biology and regenerative medicine.
