About the Editors
Doctor Hiroaki Kitano, The Systems Biology Institute, Japan
Hiroaki Kitano is a Japanese scientist, a pioneer in systems biology, and a world expert in artificial intelligence and robotics. Kitano heads the Systems Biology Institute, one of the first research institutes dedicated to systems biology established in 2000, as well as being President and CEO of Sony Computer Sciences Laboratory Inc. He is considered the father of AIBO, the first autonomous robot ever sold to general consumers. He also founded RoboCup, the international robot soccer competition, which has led to the development of technology used in rescue robots and automated warehousing, among other applications.
Kitano has played a key role in shaping a whole new discipline outside robotics. Systems biology employs modern computing to studying systems as an integrated whole and is part of research programs at universities and institutes around the world. Furthermore, he is group director of the Laboratory for Disease Systems Modeling at RIKEN Center for Integrative Medical Sciences. He is a professor at Okinawa Institute of Science and Technology (OIST), where he heads the Open Biology Unit. Kitano is active in the World Economic Forum, especially at their Global Agenda Council. He was an invited artist for La Biennale di Venezia and at “Workspheres" exhibition at Museum of Modern Art New York (2000), La Biennale di Venezia (2001) and received a special prize at Prix Ars Electronica in 2000. In 2009, Kitano was awarded the Nature Award for Creative Mentoring in Science.
Kitano is leading a team of Associate Editors and an Editorial Board representing the full scope of the interdisciplinary nature of the journal.
Professor Roland Eils, German Cancer Research Center, Germany
Roland Eils heads the Division of Theoretical Bioinformatics at the German Cancer Research Center – DKFZ in Heidelberg. He is also founding and acting director of BioQuant, Heidelberg University’s systems biology center. His research interest lies in deciphering complex pathomechanisms in diseases by an integrated genomics, imaging and computational modeling approach. He has coordinated a number of national and international systems biology and cancer genomics research programs and served twice as organizer of the International Conference on Systems Biology.
Professor Stefan Hohmann, University of Gothenburg, Sweden
Stefan Hohmann, born 1956, earned a PhD in microbiology and genetics at the Technical University of Darmstadt, Germany. After several years in Leuven, Belgium and stays in South Africa he moved to Gothenburg, Sweden in 1996. His group has been studying signal transduction and stress responses employing quantitative experimentation and mathematical modelling in collaboration with theoreticians. In particular the team focuses on mechanisms that control the dynamic profiles of signalling activity and the underlying design principles. Yeast is the experimental model organism. Mitogen-activated protein kinase pathways, in particular the osmostress-controlled HOG pathway, and the AMP-activated protein kinase pathways are main topics. Studying the dynamics of signalling systems at single cell level has recently been a focus of his group. Employing signalling pathways for cell programming in synthetic biology approaches will become an even more important line of research activities. Stephen Hohmann has an interest in the organisation of interdisciplinary education. He has arranged several large international conferences, including the International Conference of Systems Biology.
Professor Peter Hunter, The University of Auckland, New Zealand
Peter Hunter holds engineering degrees from the University of Auckland and a DPhil (PhD) in Physiology from Oxford University. He is currently a Professor of Engineering Science and Director of the Bioengineering Institute at the University of Auckland. As co-Chair of the Physiome Committee of the International Union of Physiological Sciences (IUPS) he has been helping to lead the international Physiome Project, which aims to use computational methods for understanding the integrated physiological function of the body in terms of the structure and function of tissues, cells and proteins, and has been developing the standards (CellML and FieldML) to facilitate reproducible multi-scale modeling. He is an elected Fellow of the Royal Society (London and NZ), the World Council for Biomechanics and the International Academy of Medical & Biological Engineering (IAMBE). He is currently Secretary-General of the World Council for Biomechanics and Chair-Elect of IAMBE.
Professor Edda Klipp, Humboldt-Universität zu Berlin, Germany
Edda Klipp has been full professor for Theoretical Biophysics at Humboldt-Universität zu Berlin since 2008. She has a doctoral degree in theoretical biophysics and held a position as research scientist at Humboldt-Universität following a postdoctoral period in Berlin. From 2001 to 2006, she was junior research group leader in “Kinetic modeling” before taking over the head of the research group “Computational Systems Biology” at Max-Planck Institute for Molecular Genetics until 2008. In 2009 she was awarded an honorary doctor of Göteborg University. Professor Klipp carries out multi-disciplinary research projects to understand cellular organization, dynamics of cellular processes and stress response. Her group has long-standing experience in computational systems biology with focus on dynamic modeling of regulatory processes including signaling, cell cycle, metabolism, transcriptional regulation and growth control. Methods comprise dynamic modeling with ODE systems, dynamic systems theory, parameter estimation, sensitivity analysis, and SBML models as well as spatial modeling and discrete network modeling. There is long tradition in close interaction with experimental biologists and scientists of diverse fields. Professsor Klipp is a founding member of the International Society of Systems Biology, member of several scientific advisory boards for systems biology consortia and institutions and she is principal investigator in several European and national research consortia for systems biology. She organizes a graduate program in Computational Systems Biology in Berlin.
Doctor Nicolas Le Novere, the Babraham Institute, United Kingdom
Nicolas Le Novère is senior group leader at the Babraham Institute in Cambridge (UK). He studied molecular biology and biochemistry at École Normale Supérieure, evolution at University Paris XI, biophysics and pharmacology at University Paris VI where he received a PhD in 1998. His early career at the Pasteur Institute focused on brain nicotinic receptors and their role in tobacco addiction, using both experimental and computational approaches. He moved to systems biology while modeling bacterial chemotaxis at the University of Cambridge (UK). His research then centered on inter and intra-cellular signals, with a particular emphasis on synaptic plasticity. First at EMBL-EBI and then at the Babraham Institute, he coordinated the development of key software tools to support computational systems biology research, such as BioModels, and was a major figure behind the development of a coordinated set of standards, including the MIRIAM guidelines, SBO and SBGN.
Doctor Mariko Okada, RIKEN, Japan
Mariko Okada (Hatakeyama) is professor at the Institute for Protein Research, Osaka University Japan. She started her science career with her motivation to understand molecular mechanisms of “specificity”. She is originally biochemist working on ensymes, and started a new project, in former RIKEN Genome Sciences Center, on systems biology of signal transduction network to understand cell fate decision mechanisms. Her expertise is integration of signaling and transcriptional networks using Omics and modeling approaches. She is particularly interested in “multi-scale cooperativity” arising from biological networks. Her research interests include signal-transcription network of cancer, inflammation and immune signaling, Omics data integration, and whole cell modeling of biochemical networks.
Professor John Tyson, Virginia Tech, USA
For 40 years John Tyson has been publishing mathematical models of the molecular regulatory networks that underlie many aspects of cell physiology, including cell cycle regulation, cell signaling, programmed cell death, cell clocks and switches. Some of his papers are classics in the field of systems biology, setting the standard for deterministic and stochastic models that are comprehensive, accurate and insightful. Predictions of his models have been confirmed time and again by experimental labs around the world. He is also widely respected for the clarity and scope of his papers, reviews and lectures. Dr. Tyson has spent his academic career at Virginia Tech, where he is University Distinguished Professor of Molecular Systems Biology
Professor Hiroki Ueda, University of Tokyo, Japan
Hiroki R. Ueda received his MD from the Faculty of Medicine of the University of Tokyo in 2000, and received his PhD from the University of Tokyo Graduate School of Medicine in March 2004. He was appointed team leader of Laboratory for Systems Biology in 2003 and Leader of the Functional Genomics Unit at the CDB in 2004. He was promoted to be a project leader at the Laboratory for System Biology under CDB’s Center Director’s Strategic Program from September, 2009 – September, 2014. He was also appointed as a manager of Functional Genomics Unit at the CDB from October, 2004 - March, 2013 and a head of laboratory for synthetic biology at RIKEN Quantitative Biology Center (QBiC) from April, 2011. He became a professor of Graduate School of Medicine and Faculty of Medicine of the University of Tokyo from October, 2013.
Doctor Marc Vidal, Harvard Medical School, USA
During his PhD training, Doctor Vidal discovered two new yeast genes, SIN3 and RPD3, and demonstrated their function in global transcriptional regulation. Together with the subsequent biochemical identification of histone deacetylase as the product of RPD3, his work helped confirm the Allfrey hypothesis concerning the role of histone modifications in transcriptional regulation, which is widely considered as one of the major events that sparked the field of modern epigenetics.
Since the mid 90s, Doctor Vidal has focused his attention on understanding complex macromolecular networks and systems operating inside cells. Originally trained as a bioengineer and a geneticist, he pioneered the concept of “interactome network modeling”, which is based on interdisciplinary strategies developed with collaborators from the fields of physics, computer science, mathematics, genomics and human genetics. Working closely with an extended network of colleagues and collaborators, he has discovered fundamental systems properties in the human interactome network and is now starting to unravel fundamental relationships between cellular systems and human disease.