npj Systems Biology and Applications

npj Systems Biology and Applications

Alzheimer’s disease rewires gene coexpression networks coupling different brain regions

Sanga Mitra
Kailash BP
Manikandan Narayanan

Article 09 May 2024

Featured

Positive-unlabeled learning identifies vaccine candidate antigens in the malaria parasite Plasmodium falciparum

Renee Ti Chou
Amed Ouattara
Michael P. Cummings
ArticleOpen Access27 Apr 2024
Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics

Daniel C. Kirouac
Cole Zmurchok
Denise Morris
ArticleOpen Access18 Mar 2024
Forum on immune digital twins: a meeting report

Reinhard Laubenbacher
Fred Adler
Tjalf Ziemssen
PerspectiveOpen Access16 Feb 2024
MarkerMap: nonlinear marker selection for single-cell studies

Wilson Gregory
Nabeel Sarwar
Bianca Dumitrascu
ArticleOpen Access14 Feb 2024

Announcements

npj Systems Biology and Applications Journal Metrics

npj Systems Biology and Applications has a 2-year impact factor of 4.0 (2022), article downloads of 224,006 (2022) and 8 days from submission to first editorial decision (2022).
Call for papers on phenotypic landscapes of biological

This collection calls for papers combining omics datasets to unravel the mechanisms of phenotypic stability associated with the topology and function of biological networks.
Call for papers: Methodological developments in systems

This collection calls for papers that focus on the latest computational and modelling developments in systems biology research.

Open for submissions
Call for papers on mathematical oncology

Mathematical and computational oncology are rapidly emerging as critical areas of research that aim to understand the intricate and complex nature of cancer. We invite submissions from both early career and senior researchers, and particularly encourage research with high translational value.

Open for submissions

Browse articles

Understanding flux switching in metabolic networks through an analysis of synthetic lethals

Sowmya Manojna Narasimha
Tanisha Malpani
Karthik Raman
ArticleOpen Access17 Sept 2024
Optimal performance objectives in the highly conserved bone morphogenetic protein signaling pathway

Razeen Shaikh
Nissa J. Larson
Gregory T. Reeves
ArticleOpen Access14 Sept 2024
Tipping-point transition from transient to persistent inflammation in pancreatic islets

Thomas Holst-Hansen
Pernille Yde Nielsen
Ala Trusina
ArticleOpen Access12 Sept 2024
EpiScan: accurate high-throughput mapping of antibody-specific epitopes using sequence information

Chuan Wang
Jiangyuan Wang
Taijiao Jiang
ArticleOpen Access09 Sept 2024
Codon usage and expression-based features significantly improve prediction of CRISPR efficiency

Shaked Bergman
Tamir Tuller
ArticleOpen Access03 Sept 2024
A Boolean model explains phenotypic plasticity changes underlying hepatic cancer stem cells emergence

Alexis Hernández-Magaña
Antonio Bensussen
Elena R. Álvarez-Buylla
ArticleOpen Access02 Sept 2024
Network topology and interaction logic determine states it supports

Tomáš Gedeon
Review ArticleOpen Access28 Aug 2024
Recovering biomolecular network dynamics from single-cell omics data requires three time points

Shu Wang
Muhammad Ali Al-Radhawi
Eduardo D. Sontag
ArticleOpen Access27 Aug 2024
Constraint-based modelling predicts metabolic signatures of low and high-grade serous ovarian cancer

Kate E. Meeson
Jean-Marc Schwartz
ArticleOpen Access24 Aug 2024

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Open PI Positions at Shenzhen Bay Laboratory

Through building a collaborative science and innovation community in the Greater Bay Area, SZBL strives to become the new global hub for life science.

Shenzhen, Guangdong, China

Shenzhen Bay Laboratory
Global Scientist Interdisciplinary Forum • Autumn 2024

Southern University of Science and Technology; School of Medicine & School of Public Health and Emergency Management;

Shenzhen, Guangdong, China

Southern University of Science and Technology, School of Medicine
Faculty Positions in Center of Bioelectronic Medicine, School of Life Sciences, Westlake University

SLS invites applications for multiple tenure-track/tenured faculty positions at all academic ranks.

Hangzhou, Zhejiang, China

School of Life Sciences, Westlake University
Head of the Translational Cancer Research Laboratory

Northwell Health has formed a strategic partnership with the NCI-designated Cancer Center at Cold Spring Harbor Laboratory (CSHL). The institutions...

Manhasset, New York

Northwell
Director of the Institute of Cancer Research and Robert and Janet Perro Endowed Chair

Northwell Health has formed a strategic partnership with the NCI-designated Cancer Center at Cold Spring Harbor Laboratory (CSHL). The institutions...

Manhasset, New York

Northwell

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