npj Systems Biology and Applications

npj Systems Biology and Applications

A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions

Rohit Rao
Cynthia J. Musante
Richard Allen

Article 14 April 2023

Featured

Understanding repertoire sequencing data through a multiscale computational model of the germinal center

Rodrigo García-Valiente
Elena Merino Tejero
Antoine H. C. van Kampen
ArticleOpen Access16 Mar 2023
Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms

Suchana Chakravarty
Christian I. Hong
Attila Csikász-Nagy
ArticleOpen Access11 Feb 2023
Design principles of improving the dose-response alignment in coupled GTPase switches

Lingxia Qiao
Pradipta Ghosh
Padmini Rangamani
ArticleOpen Access31 Jan 2023

Announcements

npj Systems Biology and Applications Journal Metrics

npj Systems Biology and Applications has a 2-year impact factor of 4.671 (2021), article downloads of 227,479 (2021) and 9 days from submission to the first editorial decision (2021).
Meet the Editor-in-Chief

Get to know our new Editor-in-Chief, Prof. Mohit Kumar Jolly, as he answers 5 questions about his research and experience and shares his thoughts about becoming involved with the journal.
Call for papers on Systems Immunology

We are calling for papers for a Collection on System Immunology. This Collection will cover systems immunology tools, methods, concepts and techniques to uncover mechanisms underlying immunological cell-states and their disorders.

Open for submissions

Browse articles

Identification of Probucol as a candidate for combination therapy with Metformin for Type 2 diabetes

Ranjitha Guttapadu
Kalyani Korla
Nagasuma Chandra
ArticleOpen Access23 May 2023
Effective dose window for containing tumor burden under tolerable level

M. A. Masud
Jae-Young Kim
Eunjung Kim
ArticleOpen Access23 May 2023
A multiscale chemical-mechanical model predicts impact of morphogen spreading on tissue growth

Alireza Ramezani
Samuel Britton
Weitao Chen
ArticleOpen Access20 May 2023
Metabolic function-based normalization improves transcriptome data-driven reduction of genome-scale metabolic models

Mahdi Jalili
Martin Scharm
Ali Salehzadeh-Yazdi
Brief CommunicationOpen Access20 May 2023
An automated workflow for multi-omics screening of microbial model organisms

Stefano Donati
Matthias Mattanovich
Douglas McCloskey
ArticleOpen Access19 May 2023
A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions

Rohit Rao
Cynthia J. Musante
Richard Allen
ArticleOpen Access14 Apr 2023
Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections

Christoph Saffer
Sandra Timme
Marc Thilo Figge
ArticleOpen Access10 Apr 2023
High-throughput metabolomics for the design and validation of a diauxic shift model

Daniel Brunnsåker
Gabriel K. Reder
Ross D. King
ArticleOpen Access07 Apr 2023
The nonlinearity of regulation in biological networks

Santosh Manicka
Kathleen Johnson
David Murrugarra
ArticleOpen Access04 Apr 2023

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