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Volume 8 Issue 8, August 2013

Artificial cell-like chemical systems can be used as models for fundamental studies of natural biological systems and could potentially be used to develop new biotechnological applications. Such systems do not, however, typically take into account the high concentration of macromolecules that can be present in living cells. Russell Schwartz, Philip LeDuc and colleagues have now used artificial cellular systems with an integrated synthetic biology approach to show that this molecular crowding can increase the robustness of gene expression. The fluorescence microscopy image on the cover shows an artificial cell that is made from a phospholipid membrane and measures approximately 10 âμm across.

Article p602; News & Views p545

IMAGE: CHEEMENG TAN AND KRISTEN McCONNELL

COVER DESIGN: ALEX WING

Editorial

  • Heinrich Rohrer and the scanning tunnelling microscope.

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Research Highlights

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News & Views

  • Plasmons have been excited on the surface states of the topological insulator Bi2Se3.

    • Yoshinori Okada
    • Vidya Madhavan
    News & Views
  • A technique combining direct nanotube transfer with scanning probe microscopy can be used to create ultraclean one-dimensional electron systems in suspended carbon nanotubes.

    • Zhaohui Zhong
    News & Views
  • Experiments on Bi-doped silicon demonstrate the existence of atomic clock transitions that can be used to enhance the coherence of solid-state qubits.

    • Sven Rogge
    • Matthew J. Sellars
    News & Views
  • Macromolecular crowding affects the performance and robustness of gene expression in synthetic cellular systems.

    • Friedrich C. Simmel
    News & Views
  • Cascade reactions can be used to carry out logic operations on the surface of cells and identify the presence of particular collections of cell surface markers.

    • Thomas E. Schaus
    • Peng Yin
    News & Views
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Progress Article

  • This Progress Article examines the characteristic features of low-frequency electronic noise in graphene, and discusses the implications and potential applications of such noise in graphene-based electronic devices.

    • Alexander A. Balandin
    Progress Article
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Letter

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