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Volume 7 Issue 11, November 2012

Cancer initiation and progression are characterized by complex molecular and structural changes in cells and the extracellular matrix. These changes are expected to affect the mechanical properties and responses of cells and their surrounding environment. The atomic force microscope (AFM) has been used to show that cancer cells are more compliant than healthy cells. However, the relevance of these single-cell measurements performed on cells isolated from tumours has been questioned because they lack the appropriate 3D tissue environment. Marija Plodinec et al. have now used an indentation-type AFM for the nanomechanical characterization and diagnosis of breast cancer progression. This is illustrated on the cover image that shows an AFM tip probing an invasive cancer cell that is protruding above a malignant matrix-embedded cluster.

Article p757; News & Views p691

IMAGE: EVA BIELER, MARIJA PLODINEC, RODERICK LIM; ARTWORK: MARTIN OEGGERLI/MICRONAUT 2012

COVER DESIGN: ALEX WING

Editorial

  • With the rise of two-dimensional transition metal dichalcogenides, graphene is no longer the only two-dimensional crystal attracting significant interest in the research community.

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News & Views

  • Stiffness measurements of tumour biopsies and single cells show unique fingerprints that identify the different stages of cancer.

    • Małgorzata Lekka
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  • A single layer of graphene can be used as a tunnel barrier for spin injection in silicon with several advantages over other materials that have previously been used.

    • Hanan Dery
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  • The conductivity of a single graphene nanoribbon can be measured by lifting the nanoribbon off a surface with the tip of a scanning tunnelling microscope.

    • Saw Wai Hla
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  • Direct determination of carrier concentration and doping in a single nanowire is achieved by placing four electrical contacts along its sidewall.

    • Ray LaPierre
    News & Views
  • Many experiments have demonstrated that the spin direction of an electron survives for a relatively long time in an organic material. Results presented at a recent conference show how such long spin-lifetimes can be used in devices.

    • Stefano Sanvito
    • V. Alek Dediu
    News & Views
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