Two comments analyse the aspects that allowed four nanomedicine start-ups to overcome the biotech valley of death and build timely businesses
Volume 17 Issue 8, August 2022
News & Views
Field-free superconducting diode effect in noncentrosymmetric superconductor/ferromagnet multilayers
Superconducting diodes, which can operate without dissipation losses at low temperature, usually require a magnetic field to function. A well-designed multilayer device now shows a reversible, non-volatile superconducting diode effect.
Droplet GaAs quantum dots are interconnectable sources of single photons. Near-identical photons from remote GaAs quantum dots now show an interference visibility of 93% with quantum entanglement between the separate photon streams from the two sources.
Magnetic skyrmions are topological spin textures that hold potential for the development of post-von Neumann computing schemes. In coupled ferrimagnetic insulators, pinning effects and intentional distortions can lead to a ratchet-like current-driven motion of skyrmion bubbles.
Ultra-low-energy programmable non-volatile silicon photonics based on phase-change materials with graphene heaters
A non-volatile silicon photonics switch based on phase-change materials actuated by graphene heaters shows a switching energy density that is within an order of magnitude of the fundamental thermodynamic limit.
Stretchable colour-sensitive quantum dot nanocomposites for shape-tunable multiplexed phototransistor arrays
Intrinsically stretchable quantum-dot-based semiconducting nanocomposites enable the realization of shape-tunable and colour-sensitive phototransistor arrays.
High-yield solar-driven atmospheric water harvesting of metal–organic-framework-derived nanoporous carbon with fast-diffusion water channels
A metal–organic-framework-derived nanoporous carbon with intrinsically fast sorption kinetics and excellent photothermal properties enables high-yield, solar-driven atmospheric water harvesting in arid areas.
Self-adhesive bioimpedance graphene electronic tattoos enable accurate continuous blood pressure monitoring.
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery
Cell heterogeneity might impact the delivery of lipid nanoparticles (LNPs) and efficacy of messenger RNA-based therapies in vivo. Here, the authors propose an approach to measure how various LNPs deliver DNA barcodes and mRNA to cells using single-cell RNA sequencing, providing a correlation between LNP uptake and the expression of specific genes that characterize cellular subtypes.
NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis
Nicotinamide adenine dinucleotide (NAD+) is an immune modulator that was suggested as a potential treatment for sepsis, but its in vivo benefits are contradictory and its low bioavailability as a free drug hampers potential clinical translation. Here the authors show that using a lipid-coated nanoparticle to deliver NAD+ to the cell cytosol can effectively replenish the intracellular content of NAD+ and reduce the extent of the inflammatory response in mouse models of sepsis.
Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles
Activation of the STING pathway in antigen-presenting cells has been proposed as a strategy to stimulate the adaptive immune response against tumours, but its clinical application is hampered by the instability, low specificity and low cytosolic entry of natural STING agonists. Here the authors present a platform for targeted ultrasound-mediated cytosolic delivery of STING agonists that shows efficacy in different animal tumour models and improves the response to checkpoint blockade therapies.