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Volume 17 Issue 8, August 2022

Treating sepsis with nanoparticles

Artistic representation of NAD(H)-loaded nanoparticles to replenish intracellular NAD(H) pool. NAD(H) are potential immunomodulators, but they cannot diffuse across the cell membrane, which hinders their clinical applications. Direct intracellular NAD(H) delivery enabled by nanoparticles can improve cellular energy supply and prevent inflammation-induced cell pyroptosis and apoptosis, thereby reducing fatality in severe sepsis by maintaining immune and vascular homeostasis.

See Ye et al.

IMAGE: Xin Zou, University of Wisconsin-Madison. COVER DESIGN: Amie Fernandez

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