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Volume 17 Issue 3, March 2022

Three-dimensional cellular recording

The image represents a stretchable 128 field-effect transistors array distributed in multiple units of variable heights, capable of probing cells at three different depths in a microtissue for intracellular recording of neonatal rat cardiomyocytes.

See Xu

IMAGE: Yue Gu, University of California San Diego COVER DESIGN: Lauren Heslop

Matters Arising

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News & Views

  • Controllably buckling an array of vertical field effect transistors enables intracellular electrophysiological mapping with high spatial and temporal resolutions.

    • Woohyun Park
    • Chi Hwan Lee
    News & Views
  • Examining nucleic acid delivery in humanized animal models might accelerate nanoparticle optimization and potentially improve clinical translation strategies.

    • Omar F. Khan
    News & Views
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Review Articles

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  • Hybrid single-electron turnstiles are candidates as a standard for the ampere expressing it with elegant simplicity. Yet, such devices may serve as a standard for the watt with similar elegance and simplicity.

    • Marco Marín-Suárez
    • Joonas T. Peltonen
    • Jukka P. Pekola
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  • The movement of fractionalized phase defects, that can be considered as fractional solitons promising for future information technology, is observed in atomic chains formed along step edges of silicon surfaces, solitons may serve as robust, topologically protected information carriers in future information technology

    • Jae Whan Park
    • Euihwan Do
    • Han Woong Yeom
    Article Open Access
  • Holographic vector-field electron tomography reveals the three-dimensional magnetic texture of Bloch skyrmion tubes in FeGe at nanometre resolution, including complex three-dimensional modulations and fundamental skyrmion formation principles.

    • Daniel Wolf
    • Sebastian Schneider
    • Axel Lubk
    Article Open Access
  • The implementation of parity–time symmetry in a complementary metal–oxide–semiconductor process technology enables the realization of wide-band high-quality microwave generation and broadband strong microwave isolation at gigahertz frequencies.

    • Weidong Cao
    • Changqing Wang
    • Xuan Zhang
    Article Open Access
  • The extent to which mRNA delivery, as well as the cellular response to mRNA drug delivery vehicles, is conserved across species in vivo is unknown. Using species-independent DNA barcoding, the authors measure delivery in humanized, primatized and normal mice, and identify a potential mechanism driving species-dependent lipid nanoparticle delivery.

    • Marine Z. C. Hatit
    • Melissa P. Lokugamage
    • James E. Dahlman


  • Orally delivered rapamycin is an immunosuppressant that inhibits islet graft rejection in patients treated for type 1 diabetes, but it suffers from poor bioavailability, inconsistent cellular distribution and adverse reactions. Here the authors show that subcutaneous delivery of rapamycin using a polymersome platform allows for control of the drug’s biodistribution and activity on specific immune cells, which changes its mechanism of action from immunosuppression to tolerance, reduces side effects and enhances anti-inflammatory efficacy.

    • Jacqueline A. Burke
    • Xiaomin Zhang
    • Evan A. Scott
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Amendments & Corrections

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