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Volume 16 Issue 8, August 2021

Volume 16 Issue 8

Local bioorthogonal catalysis

An artistic depiction of the bioorthogonal catalytic microneedle patch, a removable device for local activation of an anticancer prodrug. This improves the clinical potential of bioorthogonal catalysis by increasing the local therapeutic efficacy of systemically administered prodrugs and lessening off-target toxicity.

Gu, Article,

IMAGE: Zhen Gu, Zhejiang University. COVER DESIGN: Tulsi Voralia.


  • Comment |

    Almost all currently used vaccines against COVID-19 consist of either non-viral or viral nanoparticles. Here we attempt to understand the reasons behind the success of such advanced nanoscale vaccine technologies compared with clinically established conventional vaccines, and the lessons to be learnt from this potentially transformative development in the adoption and acceptance of nanotechnology for medicine.

    • Thomas Kisby
    • Açelya Yilmazer
    • Kostas Kostarelos
  • Comment |

    Sharing the step-by-step procedures necessary to fabricate nanostructures could optimize efforts to achieve reproducible devices.

    • Mohammad J. Bereyhi
    • Tobias J. Kippenberg

News & Views

  • News & Views |

    Van der Waals heterostructures serve as a platform for memory devices with ultra-fast writing speeds and non-volatile retention times, motivating their use in integrated circuits and systems.

    • Thomas Szkopek
  • News & Views |

    Thanks to a stable fluorinated interphase formed on top of a Zn metal anode, a Zn metal battery shows 99.9% Coulombic efficiency and record-high Zn utilization.

    • Guojin Liang
    • Chunyi Zhi

Review Articles

  • Review Article |

    The preparation of a diverse set of 2D materials and their co-integration in van der Waals heterostructures enable innovative material design and device engineering. This Review summarizes recent advances in 2D spintronics and opto-spintronics, the underlying physical concepts and future perspectives of the field.

    • Juan F. Sierra
    • Jaroslav Fabian
    • Sergio O. Valenzuela



  • Article |

    A strain-gradient approach induced by the phase-change transition enables the observation of the flexo-photovoltaic effect in MoS2.

    • Jie Jiang
    • Zhizhong Chen
    • Jian Shi
  • Article |

    A solid–electrolyte interphase that is permeable to Zn(ii) ions but waterproof is formed using an aqueous electrolyte composition. Cycling performances in an anode-free aqueous pouch cell show promise for intrinsically safe energy storage applications.

    • Longsheng Cao
    • Dan Li
    • Chunsheng Wang
  • Article |

    The toxicity and complicated administration procedures of transition metal catalysts have hampered the applications of bioorthogonal catalysis in vivo. Here the authors fill the needles of a microneedle array patch with palladium nanoparticles deposited on titanium nanosheets and show that the device, applied locally on the skin of mouse models bearing melanoma, promotes intratumoural conversion of systemically injected caged doxorubicin into the active drug, reducing its toxicity and side effects.

    • Zhaowei Chen
    • Hongjun Li
    • Zhen Gu
  • Article |

    In this paper the authors show that nanovesicles coated with lung spheroid cell membranes expressing angiotensin-converting enzyme 2 can bind the spike protein of SARS-CoV-2, neutralizing the virus and preventing lung cell infections in murine and non-human primate models. The nanodecoys could represent a potential therapeutic agent to treat COVID-19.

    • Zhenhua Li
    • Zhenzhen Wang
    • Ke Cheng
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