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Volume 16 Issue 3, March 2021

Volume 16 Issue 3

Mechanisms of nanoparticle endocytosis

Endocytosis of nanoparticles into cells is a critical step in the delivery of therapeutic nanomedicines. However, there are a number of misconceptions surrounding the cellular pathways that govern this process. A Review by Rennick, Johnston and Parton summarises the latest insights into nanoparticle uptake, and highlights the limitations of current approaches to study these systems. An improved understanding of nanoparticle endocytosis can potentially help to harness cell biological mechanisms for more efficient therapeutic delivery. The image is an artistic representation of different types of nanoparticles being internalized by a cell.

See Rennick et al.

Image: Angus Johnston, Monash University. Cover Design: Bethany Vukomanovic.


  • Editorial |

    We have launched a series of webinars to engage our audience in a way that is complementary to the publication of articles.

News & Views

  • News & Views |

    Selective growth of nanoporous metal–organic framework nanocrystals in the stacking defects of graphene oxide layers improves the mechanical integrity and water–solute selectivity of graphene oxide membranes.

    • Xiaofang Chen
    • Huanting Wang
  • News & Views |

    In a simple bilayer structure, spin torque induced by a reduced crystal symmetry switches perpendicular magnetization reliably at zero magnetic field.

    • Soogil Lee
    • Jeongchun Ryu
    • Byong-Guk Park


  • Perspective |

    This Perspective reflects current understanding and future prospects of nanoscale biological recognition at the bio–nano interface and the opportunity that such insights provide for advancing nanoscale therapies. The authors describe the key mechanisms and propose a framework of principles that could guide future research efforts in the area.

    • Kenneth A. Dawson
    • Yan Yan
  • Perspective |

    Despite its high promise, there are still many challenges for CRISPR-mediated plant genetic engineering, yet nanotechnology can play an important role in lowering and possibly eliminating these challenges.

    • Gozde S. Demirer
    • Tallyta N. Silva
    • Markita P. Landry

Review Articles


  • Letter |

    Spin–orbit torque in heavy metal/ferromagnet heterostructures is promising for all-electric control of magnetic memory, but has so far required an additional symmetry breaking in the design to switch perpendicular magnetization. Instead, a low symmetry at the interface can give rise to out-of-plane spin torque and switch the magnetization deterministically.

    • Liang Liu
    • Chenghang Zhou
    • Jingsheng Chen
  • Letter |

    Hybrid quantum optomechanical systems interface a single two-level system with a macroscopic mechanical degree of freedom. In a microwire with a single embedded semiconductor quantum dot, not only can the wire vibration modulate the excitonic transition energy, but the optical drive of the quantum dot can also induce motion in the wire.

    • Jan Kettler
    • Nitika Vaish
    • Jean-Philippe Poizat


Amendments & Corrections

Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research


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