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Volume 16 Issue 3, March 2021

Mechanisms of nanoparticle endocytosis

Endocytosis of nanoparticles into cells is a critical step in the delivery of therapeutic nanomedicines. However, there are a number of misconceptions surrounding the cellular pathways that govern this process. A Review by Rennick, Johnston and Parton summarises the latest insights into nanoparticle uptake, and highlights the limitations of current approaches to study these systems. An improved understanding of nanoparticle endocytosis can potentially help to harness cell biological mechanisms for more efficient therapeutic delivery. The image is an artistic representation of different types of nanoparticles being internalized by a cell.

See Rennick et al.

Image: Angus Johnston, Monash University. Cover Design: Bethany Vukomanovic.

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  • Spin–orbit torque in heavy metal/ferromagnet heterostructures is promising for all-electric control of magnetic memory, but has so far required an additional symmetry breaking in the design to switch perpendicular magnetization. Instead, a low symmetry at the interface can give rise to out-of-plane spin torque and switch the magnetization deterministically.

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