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Volume 14 Issue 9, September 2019

The tendency of DNA to move down

Precision placement and transport is crucial for high-throughput autonomous molecular sorting and detection. Take nanopore sequencing as an example. The delivery of DNA molecules towards a nanopore determines the throughput and precision of the measurement. Now, using all-atom molecular dynamics, Shankla et al. find that, subject to force, molecules are more likely to move down a step defect than up the defect and are more likely to be displaced along the step defect line. The cover art depicts the tendency of adsorbed DNA molecules to move down and along the defect edge of graphene surface-step defects that separate multilayer domains. The principle can be used to guide the delivery of molecules in various technological processes.

Article by Aksimentiev et al.

IMAGE: Manish Shankla, University of Illinois. COVER DESIGN: Bethany Vukomanovic

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