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Volume 13 Issue 1, January 2018

How to resist silver

The resistance of bacteria against antibiotics represents one of the biggest issues of the 21st century. Nanotechnologies applying silver nanoparticles are considered an emerging tool in antimicrobial therapies as their action has not yet been associated with any resistance. A. Panáček, L. Kvítek, R. Zbořil and co-workers have now discovered that gram-negative bacteria repeatedly exposed to silver nanoparticles can develop resistance to their antibiotic activity. The cover is an artist’s rendition of the resistance mechanism based on the production of flagellin — an adhesive protein of bacterial flagellum, which causes nanoparticles’ aggregation and thereby eliminates their antibacterial effect. Importantly, the resistance evolves without any genetic changes and can be overcome by the addition of pomegranate rind extract inhibiting the flagellin production in bacteria.

See Panáček et al.

Image: Martin Pykal, Aleš Panáček, Libor Kvítek, and Radek Zbořil, Palacky Universitý Olomouc, Czech Republic. Cover Design: Alex Wing

Editorial

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Thesis

  • Chris Toumey revisits the 2003 exchange of opinions between Eric Drexler and Richard Smalley, which was one of the most colourful disagreements in the history of nanotechnology.

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Research Highlights

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News & Views

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Perspectives

  • This Perspective describes the fundamental principles of nano-opto-electo-mechanical systems and their applications in communication, sensing and signal transduction.

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In the Classroom

  • Failure is an unavoidable element of the process that leads to discovery and it should be embraced even in early education, says Deji Akinwande.

    • Deji Akinwande
    In the Classroom
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