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The neuronal membrane progressively collects postsynaptic potential signals from neighbouring neurons and integrates them until a threshold value is reached, resulting in an action potential being fired. Tomas Tuma, Evangelos Eleftheriou and colleagues have now reproduced this integrate-and-fire functionality by means of a single nanodevice working on a typical timescale of a nanosecond. To this end, they exploit the reversible transition between amorphous and crystalline states of chalcogenide-based phase-change materials. These devices display intrinsically stochastic dynamics, analogous to biological neurons, making them extremely appealing for applications in the field of neuromorphic computation.
Induced progressive crystallization in chalcogenide-based materials can be used to closely mimic neuronal functions, opening new paths to neuromorphic computing.
Semiconductor nanocrystals offer an enormous diversity of device applications that have been potentially limited by intermittent fluorescence intensity or 'blinking' dynamics. However, recent progress in both experiment and theory suggest a more promising outlook.
High-spatial-resolution magnetometry at cryogenic temperature can be achieved with nitrogen–vacancy centres, allowing detailed imaging of Pearl vortices in the cuprate superconductor YBa2Cu3O7−δ.
Variations in silver isotope ratio identified using inductively coupled plasma mass spectrometry offers insights into the natural transformation processes of silver nanoparticles in the environment; the approach could potentially be used to distinguish engineered silver nanoparticles from those formed naturally.
Measuring the binding force between red blood cells and fibrinogen — the protein that helps in the formation of blood clots — using an atomic force microscope can help identify patients at increased risk of cardiovascular disease.
Nanoscale magnetic imaging based on single defects in diamond is extended to cryogenic temperatures and is used to study vortices in the iron pnictide superconductor BaFe2(As0.7P0.3)2.
Hundreds of molecular rotors in a 2D network can be simultaneously rotated by applying an electric field from the tip of a scanning tunnelling microscope.
A wild-type aerolysin nanopore can resolve individual short oligonucleotides that are 2 to 10 bases long, and can monitor the stepwise cleavage of oligonucleotides by exonuclease I.
High-speed atomic force microscopy can visualize the dynamics of phenylalanine-glycine nucleoporins inside nuclear pore complexes and reveals the selective barrier mechanism within these molecular machines.
A magnetic resonance imaging contrast agent that amplifies its signal in response to pH is used to rapidly identify tumours, report hypoxic regions in the tumour and detect millimetre-sized metastatic tumours in the liver of animals.