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A method for overcoming antibiotic resistance uses multimodal nanoparticles that target bacterial defence mechanisms while enhancing the innate immune response.
A double-blind, randomized, controlled human exposure trial of highly purified and thin nanometre-sized graphene oxide nanosheets shows that acute inhalation of aerosolized nanoparticles is not associated with harmful effects in healthy humans.
Robotics and machine learning are combined to predict and prepare a variety of nanocomposite materials with properties mimicking those of various types of plastics, starting from natural building blocks.
A genetically engineered variant of the stimulator of interferon genes (STING) protein is delivered to cancer cells, showing potential for clinical impact.
A distance-based mapping strategy using single-molecule fluorescence resonance energy transfer via DNA eXchange (FRET X) enables full-length fingerprinting of intact protein sequences.
The performance of three-terminal molecular transistors is enhanced through the harnessing of quantum interference in the edges of graphene electrodes.
An aptamer-based nanobiosensor has been integrated into a wearable sweat sensor, allowing non-invasive tracking of the female reproductive hormone, oestradiol, with the potential to deliver sustainable solutions to female reproductive healthcare needs.
Chitosan/glucose co-polymers encapsulating silver sulfide quantum dots can be used to improve oral delivery of insulin in different animal models without hypoglycaemic incidents.
Electrochemical carbon dioxide (CO2) reduction in acid with a nano-structured tandem catalyst achieves high single-pass conversion efficiency and selectivity to useful C–C coupled products, bringing the process closer to commercial viability.
Conserved regions of the circular DNA sequence of the M13mp18 bacteriophage, which is used as a scaffold for DNA origami construction, are targeted with specific hybridization-chain-reaction probes. The probes enable sensitive detection of DNA origami nanostructures in cells, organoids and tissues to assess their biodistribution and stability.
A biohybrid, leaf-spring design of DNA origami functions as a pulsating nanoengine that exploits the DNA-templated RNA transcription mechanism while consuming nucleoside triphosphates as fuel. The nanoengine also drives a nanomechanical follower structure.
Directionality of nonlinear emission from a dielectric metasurface is controlled by fine-tuning the relative time delay and polarization of two pulsed pump beams.
To determine the physiologically relevant oligomeric form of membrane proteins is extremely challenging. Now an elegant method of counting the oligomers in membrane proteins in near-native states is presented, using photobleaching and nanodiscs formed directly from cellular membranes.