Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A soft artificial retina with flexible phototransistors and three-dimensional liquid-metal microelectrodes is used to enhance proximity to retinal ganglion cells and minimize damage to soft tissue as well as improve charge injection for vision restoration in retinal degenerative in vivo models.
As singularities in non-Hermitian systems, exceptional points exhibit rich topological characteristics and have potential for sensing applications. Now, a nitrogen-vacancy spin in diamond exhibits a third-order exceptional line upon the introduction of multiple symmetries in the non-Hermitian Hamiltonian of the spin system.
Multidimensional optical information, including intensity, polarization and wavelength, can be simultaneously detected using double twisted black arsenic–phosphorus homojunctions.
A one-step spin-coating approach to fabricate scalable epitaxial heterodimensional tin perovskite thin films results in near-infrared tin perovskite LEDs with a peak external quantum efficiency of 11.6%.
Protein degradation is a powerful tool for a range of applications and therapies. Here, a selective autophagy receptor mimetic against mutant p53 protein is developed to substantially elevate autophagy levels and to recognize and transport mutant proteins for autophagy-mediated degradation and anticancer effect.
Bidirectional neural interface electronic devices offer therapeutic options. Here, the authors present wafer-scale fabrication of flexible nanoporous graphene-based implantable microelectrode arrays with low impedance and high charge injection for in vivo brain recording and nerve stimulation.
Cytokine interleukin-12 (IL-12) has potential for tumour suppression yet off-target effects limit potential applications. Here the authors report on the delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation and demonstrate the immunotherapeutic potential of targeted cytokine mRNA therapy.
High-density transparent microelectrode arrays with platinum-nanoparticle deposited and interlayer-doped double-layer graphene enable multimodal optical and electrical recordings with high spatiotemporal resolution to decode neural dynamics at different cortical layers from surface potentials.
A metasurface-based approach is used to implement computationally expensive digital convolution operations in high-speed, low-power optics for improving the latency and power consumption of machine vision systems.
By preadsorption of water molecules on a material surface, a controllable ångström-scale van der Waals (vdW) gap is created, which can be applied to other vdW material systems with controllable gaps.
Nanofibre lung injury has previously been linked to the leakage of reactive oxygen and nitrogen species in frustrated phagocytosis. Here the authors use a nanosensor to demonstrate, map and track the generation of reactive species during the frustrated phagocytosis of model glass nanofibres.
Here, 3D nanofabrication and elasticity programming of monolithic soft microrobots equipped with magnetic springs with strain response at piconewton forces capable of deformation on micrometre length scales is demonstrated for applications in cell force sensing, cell manipulation and soft actuation.
An atomically thin indium tin oxide film in the form of a quantum well exhibits a χ2 of ~1,800 pm V–1. Theoretical calculations point to an asymmetric electronic interband transition resonance as the reason for this large χ2 value.
Insulin injections are not ideal and have an increased risk of hypoglycaemia. A preferable oral formulation based on silver sulfide quantum dots coated with a chitosan/glucose polymer is discussed, which has controlled insulin release and reduced risk of hypoglycaemia, and demonstrates applications in rodent and non-human primate models.
Nanoparticle clearance is critical for safety and therapeutic applicability. Here the authors report the modulatory role of microglial extracellular vesicles on the brain clearance of organic and inorganic nanoparticles and provide a strategy to control their intracerebral fate.
Fluorinated elastomers as photoresists in the fabrication of soft neural probes are used to enhance the spatiotemporal recording capability at single-neuron resolution within the central nervous system of rodents.
Using hydrogel nanovials to capture single mesenchymal stromal cells and their growth factor secretions, the authors link cell secretion to the transcriptome for thousands of cells, SEC-seq, enabling the study of secretion-associated cell states and mechanisms in therapeutic cell types.
The interference between two frequency-degenerate upconversion processes enables a metasurface-based, all-optical routing by controlling the phase delay between pump beams.
The level of immune response in cancer vaccines can limit application. Here, an immune mobilization strategy, using bacteria-derived nanovesicles, enhances therapeutic outcomes of tumour vaccination by stimulating interleukin-1β secretion to elicit trained immunity with lineage shifts and epigenetic changes in myeloid progenitor pools.
High-energy interlayer excitons in van der Waals semiconducting transition metal dichalcogenides lie far above the bandgap and emit in the ultraviolet range.