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Volume 12 Issue 12, December 2017

Small-molecule-based fluorescent probes can generally detect and image one type of protein via specific binding while cross-reactive sensor arrays can discriminate among multiple different proteins via pattern-based recognition. David Margulies and colleagues developed a pattern-generating fluorescent molecular probe that combines the properties of both. This probe can produce unique fluorescence fingerprints for specific protein groups, allowing it to identify various members of these groups in biofluids and living cells, where comparable macroscopic analytical devices cannot access. The cover image is an artist's impression of the way proteins can be identified within cells via pattern-based detection.

Article p1161

IMAGE: TALI WIESEL (DESIGN, PHOTOGRAPHY AND PRINTING BRANCH, RESEARCH SERVICES DIVISION, WEIZMANN INSTITUTE OF SCIENCE)

COVER DESIGN: DAVID SHAND

Editorial

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Commentary

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Research Highlights

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In the Classroom

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