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  • Reducing cancer-related deaths can only happen with a better understanding of cancer biology and the development of improved, new therapeutics and delivery mechanisms. Nearly all cancer research is dependent upon the models being used, the model’s accuracy, and appropriate validation and benchmarking. Here the need for such considerations is discussed in line with the goal of the Cancer Moonshot.

    • Peter C. Searson
  • Nanotechnology is advancing at an accelerated pace in applications and novel nanomaterials. To become an enabling technology for a more sustainable society, we identify and assess nanomaterials and applications trends with potentially significant environmental implications.

    • Arturo A. Keller
    • Alex Ehrens
    • Bernd Nowack
  • Increasing the capacity of biological nitrogen fixation (BNF) is an effective strategy to enhance food security while simultaneously reducing the carbon and nitrogen footprint of agriculture. Nanotechnology offers several pathways to enhance BNF successfully.

    • Mingshu Li
    • Li Gao
    • Peng Zhang
  • Nanomedicines are complex drugs where components that have typically been regarded as excipients may now be considered part of the active ingredient. The distinction between the active ingredient and excipients for nanomedicines has important consequences for regulatory review and product development. The dissimilarity in the review of the recent ribonucleic acid (RNA)-based lipid nanoparticles highlights the need for further regulatory alignment on this topic.

    • Eva Hemmrich
    • Scott McNeil
  • Recent advancements in DNA nanotechnology are enabling the construction of both aesthetically pleasing and functional structures using synthetic DNA strands, paving the way for practical applications in various fields.

    • Francesco Ricci
    • Hendrik Dietz
  • Since the early 1990s, the intersection of genetics and nanomedicine has found a home in the clinic as one of the game changers of the past decade, holding great promise in fighting diseases by rapidly developing much-needed therapeutic platforms, from cancer to infectious or genetic diseases. And this revolution was just triggered by the amazing evolving world of messenger RNA and its ‘cues’.

    • João Conde
    • Robert Langer
    • José Rueff
  • Waste containing nanomaterials — or nanowaste — is an emerging safety concern worldwide, warranting specific environmentally sound waste management and regulation.

    • Fabienne Schwab
    • Barbara Rothen-Rutishauser
    • Alke Petri-Fink
  • Perovskite quantum dots have been proven promising for photonic and optoelectronic applications, particularly, as bright and narrow band emitters for display technology. Despite the advantageous properties, the stability issues have to be resolved to unleash the full industrial potential of perovskite quantum dots in display technology.

    • Xian-gang Wu
    • Honglei Ji
    • Haizheng Zhong
  • Using our company’s CO2 electrolysers as a model, we describe the challenges involved in incorporating nanomaterial catalysts into industrial-scale electrolysers and suggest ways to more efficiently realize the performance improvements of academic-scale novel nanomaterials at industrial scales.

    • Aya K. Buckley
    • Sichao Ma
    • Kendra P. Kuhl
  • The transition from a linear ‘take–make–dispose’ economy to a circular economy is gaining momentum. Although there are many opportunities for using nanotechnology to enable circularity, the knowledge gaps related to (eco-)toxicological hazards and the presence of nanomaterials in waste streams constitute significant challenges.

    • Steffen Foss Hansen
    • Rickard Arvidsson
    • Alessio Boldrin
  • Nanoneedle start-ups are traversing the biotech valley of death — from fundamental university research into commercial development in advanced therapeutics and diagnostics. How can academics make the most of this opportunity?

    • Roey Elnathan
    • Andy Tay
    • Ciro Chiappini
  • Silicon spin qubits have demonstrated some promising properties at the individual level, but the technology is beleaguered by a late start and high barriers to entry. To overcome these challenges, the quantum computing and electrical engineering communities will need to find novel ways to work together.

    • Maud Vinet
  • Molecules have the potential to act as sharp energy filters for electrical currents and could thereby outperform other materials considered for thermoelectric energy conversion. Yet, there is a gap between theoretical predictions and practical implementations in molecular thermoelectricity, and this research roadmap may guide the transition from academic research to valuable technology.

    • Andrea Gemma
    • Bernd Gotsmann
  • A common understanding of the key regulatory term “substance” is needed for the implementation of chemicals regulations for nanomaterials.

    • Bernadette M. Quinn
  • The halide perovskite family has, arguably, become today’s most promising emerging materials sets for optoelectronic applications. Here, we discuss the underperformance to date of the colloidal nanocrystal forms of these materials when employed in electroluminescent lighting devices relative to their counterparts, in which the emitter layer is in the form of polycrystalline films. However, we highlight the bright future of halide perovskite colloidal nanocrystals in light-emission technologies such as LCD displays, quantum light sources and even alternative LED configurations, as well as key guidelines for their further development to get there.

    • Javad Shamsi
    • Gabriele Rainò
    • Samuel D. Stranks