Articles

A reagentless, wireless, wearable aptamer nanobiosensor interfaced with a gold nanoparticle-MXene-based electrode enables the selective, automatic and non-invasive analysis of the female hormone oestradiol in sweat during menstrual cycles with subpicomolar sensitivity.

This study establishes a method for multiplexed detection of up to 40 different biomarkers in a single assay by combining nanopore sequencing with analyte-selective barcoded probes, including cardiac disease-associated microRNA directly from blood serum.

Biosynthesis of magnetosomes is of interest for a range of applications. Here, factors needed for magnetosome biosynthesis are evaluated and new diverse bacteria are engineered to biofabricate magnetic nanoparticles, facilitating translation to biotechnology and nanomedicine.

Here, the authors find a decrease in hepatic phagocytic uptake of nanoparticles in old mice due to age-associated downregulation of the scavenger receptor MARCO, which led to improved tumour delivery and antitumour efficacy of cancer nanomedicine, showing the need to consider age as a factor in therapeutics.

Nanoparticle penetration into tumours is an obstacle to cancer therapeutics. Here the authors show that the tumour vascular basement membrane constitutes a barrier that reduces nanoparticle delivery and demonstrate an immune-driven strategy to overcome the barrier, increasing nanoparticle movement into tumours.

Quantum biological electron transfer has potential in diagnostic and therapeutic settings. Here the authors report the triggered apoptosis of cancer cells using electricical input to wirelessly induce redox interactions at bio-nanoantennae in proximity to cancer cells.

Non-invasive monitoring of oxygen levels has implications in a wide range of applications. Here, the authors report that biological imaging beyond 1,500 nm enables in vivo quantitative assessment of oxyhaemoglobin saturation at vascular resolution with high sensitivity.

A transfer approach for monolayer MoS₂ using polypropylene carbonate shows a negligible residue coverage of ~0.08% and an ultralow Ohmic contact resistance of ~78 Ω µm, with an excellent on/off ratio of ~10¹¹ at 15 K.

A free-standing two-dimensional sheet composed solely of Mo atoms shows metallic character, with an electrical conductivity of ~940 S m⁻¹.

We developed a technique to fabricate atomically precise quantum antidots with unprecedented robustness and tunable quantum hole states through self-assembled single vacancies in a two-dimensional transition metal dichalcogenide.

An efficient control strategy is designed for quantum dot arrays, drawing inspiration from classical semiconductor technology. A two-dimensional array of 16 semiconductor quantum dots is operated using only a few shared control lines.

Lithographically assisted, precise arraying of three-dimensional DNA origami nanostructures allows the fabrication of molecularly addressable nanotextured surfaces from the micro- to millimetre scales.

Dirac magnetoexcitons with non-trivial nanoscale electrodynamics are formed from the excitation of Landau levels in charge-neutral graphene. Here, the Dirac magnetoexciton dispersion is directly imaged up to 7 T via a magneto cryogenic near-field microscope.

An untethered phototactic soft machine composed of poly(N-isopropylacrylamide) hydrogel blended with graphene oxide and gold nanoparticles demonstrates underwater full-space artificial phototaxis and manoeuvres around obstacles in natural sunlight.

A synthetic nanocarrier based on DNA origami chassis offers control over valency, orientation and spatial arrangement of antibodies for simultaneously engaging immune signalling pathways, checkpoint inhibition and targeted co-stimulation in anticancer immunotherapy in vivo.

The energy position of the van Hove singularity in a van der Waals flat-band system is detected by tunnelling (photo)currents within a field-effect structure.

Confocal optical microscopy is used to visualize—at high speed—solid (particle volume changes and phase-front velocities) and liquid electrolyte (concentration polarization gradients) dynamics inside operating batteries.

DNA-based point accumulation in nanoscale topography (DNA-PAINT) super-resolution imaging reveals the kinetics of the free energy of base-stacking interactions of all 16 dinucleotide combinations at the single-molecule level in patterned DNA-origami nanostructures.

A giant spin Hall effect with long spin diffusion length and coexisting with ferromagnetism is observed in AB-stacked MoTe₂/WSe₂ moiré hetero-bilayers.

DNA nanotechnology is used to develop fully synthetic, programmable and printable 3D cell-culture matrices with stress-relaxation crosslinkers that encode (nano)mechanical stability. The hydrogel performs on par with solubilized animal-basement-membrane-derived cell-culture matrices.