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Cryo-electron microscopy uncovers the interfacial failure mechanism of lithium metal anodes at the atomic scale, informing a F-rich solid-electrolyte interface design strategy for highly-reversible solid-state Li metal batteries.
The transition from a linear ‘take–make–dispose’ economy to a circular economy is gaining momentum. Although there are many opportunities for using nanotechnology to enable circularity, the knowledge gaps related to (eco-)toxicological hazards and the presence of nanomaterials in waste streams constitute significant challenges.
Superconducting diodes, which can operate without dissipation losses at low temperature, usually require a magnetic field to function. A well-designed multilayer device now shows a reversible, non-volatile superconducting diode effect.
Li-metal surfaces can be effectively protected against corrosion using fluoroethylene carbonate, leading to a conformal and stable solid–electrolyte interphase.
Cell heterogeneity might impact the delivery of lipid nanoparticles (LNPs) and efficacy of messenger RNA-based therapies in vivo. Here, the authors propose an approach to measure how various LNPs deliver DNA barcodes and mRNA to cells using single-cell RNA sequencing, providing a correlation between LNP uptake and the expression of specific genes that characterize cellular subtypes.
Information thermodynamics offers a route to measure how effectively a light-driven molecular machine converts energy from absorbed photons into pumped motion.
Nanoneedle start-ups are traversing the biotech valley of death — from fundamental university research into commercial development in advanced therapeutics and diagnostics. How can academics make the most of this opportunity?
A theoretical model captures the thermodynamic principles behind the functioning of an out-of-equilibrium photoactivated artificial molecular pump in a quantitative manner.
We will now explicitly ask reviewers to flag up to us and authors whether a simpler model or theory could explain the experimental data in a given manuscript.
This Perspective suggests a characterization cascade for nanoparticle-based vaccines that takes into consideration the complexity of the materials and of their immunomodulatory responses, providing a roadmap for the preclinical validation of potential vaccine candidates.
Nicotinamide adenine dinucleotide (NAD+) is an immune modulator that was suggested as a potential treatment for sepsis, but its in vivo benefits are contradictory and its low bioavailability as a free drug hampers potential clinical translation. Here the authors show that using a lipid-coated nanoparticle to deliver NAD+ to the cell cytosol can effectively replenish the intracellular content of NAD+ and reduce the extent of the inflammatory response in mouse models of sepsis.
Light harvesting in photosynthesis and photovoltaics may rely on quantum-coherent energy transfer, but experimental verification is hindered by the lossy nature of the molecular systems. Subnanometre-resolved electroluminescence spectroscopy now reveals wavelike intermolecular electronic energy transfer through quantum coherence in artificially constructed donor–acceptor heterodimers at the single-molecule level.
Nanostructured fibres with highly aligned and alternating crystalline and amorphous domains created from triblock copolymers exhibit excellent mechanical properties, multi-trigger actuation, high-performance contraction and on/off rotation.
A frequency filtering method can efficiently remove the autofluorescence background and light scattering during in vivo visible and near-infrared experiments.
An optical technique is developed that extends the capabilities of fluorescent nanosensors into previously inaccessible ultradeep in vivo locations, including the brain, without the use of fibre optic or cranial window insertion.
