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A nanoscale printing method is developed to fabricate three-dimensional high-refractive index photonic crystals whose bandgap spans in the entire visible range.
Creating precise morphogen gradients for tissue engineering is challenging. Here the authors present mechanically tunable DNA hydrogel-based microbeads for light-controlled morphogen release in retinal organoids for better tissue mimicry.
This work employs nano- to microscale characterization to identify different structural change pathways associated with non-homogeneous reactions within the particles, and explores differences in the failure mechanisms of lithium-rich transition metal oxide materials at different current densities.
Orally administrable and glucose-responsive worm-like micelles have been developed to protect insulin in the gastrointestinal tract, enhance its intestinal absorption, accumulate in the liver and enable efficient and safe blood-glucose management.
A DNA origami nanodevice presents its hidden death ligand pattern in the acidic tumour microenvironment to kill cancerous cells, opening opportunities for effective and safe cancer therapy.
Delivering gene editing materials to the brain for glioblastoma therapy can boost the efficacy of chemotherapy. Here the authors reduce resistance to temozolomide using a reactive oxygen species-sensitive polymer-locking fusogenic liposome that can cross the blood–brain barrier and deliver short interfering RNA or CRISPR–Cas to glioblastoma with high specificity.
Atom manipulation in a scanning tunnelling microscope allows the fabrication of artificial topological quantum magnets. Single-atom electron spin resonance experiments probe the many-body topological modes of the quantum magnets and provide a visualization.
DNA origami tension sensors, created by integrating DNA origami sheets with molecular tension probes, enable the quantification of mechanical forces involved in T cell receptor interactions at intermembrane junctions.
A dual-gradient metasurface is introduced that allows continuous control over light–matter coupling in the spectral and quality-factor parameter space. Used for molecular sensing, it achieves mode densities near the theoretical limit for metasurfaces.
In situ evaporation of Eu and As onto InAs nanowires results in the mutual exchange of Eu from the shell with In from the core. This solid-state exchange reaction converts wurtzite InAs nanowires into Zintl Eu3In2As4.
Metal-ion-chelating phenylalanine nanostructures modulate ion influx and efflux in dendritic cells, activating them through the NLRP3 inflammasome and NF-κB pathway to remodel the immunosuppressive tumour microenvironment for PD-L1-based immunotherapy.
This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.
Biodegradable glasses are a sustainable alternative to traditional glass. Here high-entropy cyclic peptide glasses are engineered, with enhanced crystallization resistance, mechanical properties and enzyme tolerance.
A new acid-degradable linker termed ‘azido-acetal’ has been developed that rapidly hydrolyses at pH 6.0 but is stable at pH 7.4. Lipid nanoparticles made with this linker delivered mRNA in vivo and in vitro better than traditional lipid nanoparticles.
