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A donor–acceptor molecule assembles with different molecular packing to form photocatalysts which selectively produce either H2 or H2O2, depending on the aggregate structure, a proof-of-concept of photoactivity polymorphism.
Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. Here we use a bottlebrush prodrug platform to show that the delivery of three drugs in a synergistic combination in animal models outperforms other combinatorial approaches for multiple myeloma therapy.
Optically active semiconductor quantum dots have so far suffered from nuclear inhomogeneity limiting all dynamical decoupling measurements to a few microseconds. Lattice-matched GaAs–AlGaAs quantum dots now enable decoupling schemes to achieve a 0.11 ms spin coherence time.
Topological magnetic monopoles are non-local spin textures that are robust to thermal and quantum fluctuations, but they are difficult to study at the nanoscale in real space. Now, soft X-ray vector ptycho-tomography is demonstrated to determine the three-dimensional magnetization vector and emergent magnetic field of such magnetic monopoles in a ferromagnetic meta-lattice.
A neuromorphic camera can localize single fluorescent particles to below 20 nm resolution and evaluate the diffusion trajectory with millisecond temporal precision.
Polymerase-chain-reaction-based methods used in clinic to identify respiratory viral infections cannot simultaneously detect multiple viruses or viral variants. Here nanopore nucleic acid sensing is coupled to programmable ribonuclease to simultaneously identify specific short RNA sequences of multiple viruses, without predetection steps such as sample purification or preamplification.
Electrons in two-dimensional semiconductor moiré materials experience competing magnetic interactions. Magneto-optical measurements of moiré devices with controlled screening of the Coulomb interactions now evidence a Wigner–Mott insulating state with frustrated magnetic interactions.
An electric field gradient can be used to control spin qubits in silicon quantum dots, enabling switchable fast single-qubit gates and, potentially, scalability.
High-performance all-electrical control is a prerequisite for scalable silicon quantum computing. The switchable interaction between spins and orbital motion of electrons in silicon quantum dots now enables the electrical control of a spin qubit with high fidelity and speed, without the need for integrating a micromagnet.
Metasurfaces can solve Fredholm integral equations of the second kind for free-space radiation at optical wavelengths. To this end, an inverse-designed metagrating is coupled to a semitransparent mirror providing feedback to perform an analogue version of the Neumann series.
Catalyst microenvironment induced by mixed CO/CO2 feeds in an alkaline membrane assembly electrolyser determines the catalytic activity and product selectivity in CO2/CO electrolysis.
Although conventional innate immune stimuli contribute to immune activation, they induce exhausted immune cells, resulting in suboptimal cancer immunotherapy. Now, a kinetically activating nanoadjuvant can dynamically integrate two waves of innate immune stimuli, in terms of the order, duration and time window, which results in effective antitumour immunity without immune cell exhaustion.
The self-assembly of a triblock bottlebrush polymer at one length scale controls the ordering of the self-assembly at a smaller scale, forming a hierarchical unit cell.
Covalent confinement drives symmetry breaking in macromolecular arrangements, giving rise to layered low-symmetry self-assemblies of mesh networks in the sub-10-nm scale.
The transport of dissolved ions inside tiny carbon nanotubes apparently violates the famous Nernst–Einstein relation, which links diffusive and electric-field-driven motion.
