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  • Here, the authors combined and synchronized single-cell nanoindentation, electrophysiology and functional fluorescence imaging to evaluate the responses of neuronal networks to mechanical stimuli with piconewton force sensitivity and nanometre precision, enabling the exploration of nanomechanobiology and manipulation of neuronal systems.

    • Krishna Chaitanya Kasuba
    • Alessio Paolo Buccino
    • Daniel J. Müller
    ArticleOpen Access
  • Manufacturing complexities, low yield and stability issues have hampered the clinical translation and scaling-up of immunoliposomes to meet the needs of pharmaceutical-grade products. The authors propose a one-step method of incorporating chimeric nanobodies tagged to hydrophobic linkers into liposomes, allowing targeted delivery of small-molecule anti-cancer drugs to tumours.

    • Md. Mofizur Rahman
    • Jing Wang
    • Yuan Wan
    Article
  • An aptamer-based nanobiosensor has been integrated into a wearable sweat sensor, allowing non-invasive tracking of the female reproductive hormone, oestradiol, with the potential to deliver sustainable solutions to female reproductive healthcare needs.

    • Fabiana Arduini
    News & Views
  • In regenerative medicine, stem-cell-derived extracellular vesicles are emerging as cell-free nanotherapeutics. Here, the authors show that coating these nanovesicles with blood proteins such as albumin improves their uptake by liver cells, offering a better treatment strategy for liver diseases.

    • Revadee Liam-Or
    • Farid N. Faruqu
    • Khuloud T. Al-Jamal
    ArticleOpen Access
  • Here the authors present a non-FRET DNA-templated silver nanocluster probe that exhibits a distinct colour switch from green to red upon nuclease digestion, visible under UV excitation, offering a low-cost, effective alternative to fluorescent reporters for detecting nuclease activities.

    • Soonwoo Hong
    • Jada N. Walker
    • Hsin-Chih Yeh
    Article
  • Distinguishing proteoforms and post-translational modifications has remained a challenge. Here the authors explore single-molecule fluorescence resonance energy transfer to probe amino acids via DNA exchange and map the location of individual amino acids and post-translational modifications within single full-length protein molecules.

    • Mike Filius
    • Raman van Wee
    • Chirlmin Joo
    Article
  • Scientists encounter pressure to validate their research work, leading to varied benchmarks and methods for performance assessment in the broad energy research field. Interlaboratory studies help highlight discrepancies in reported figures of merit, underscoring the need for standardized protocols, transparent reporting, and detailed analysis for fair comparisons. Here, we discuss this topic, focusing on battery materials.

    • Nella M. Vargas-Barbosa
    Comment
  • An encodable DNA clutch with the ability to recognize microenvironmental molecular inputs intelligently complements the remote control of a 200-nm sized magnetic nanomachine. This nanomachine interacts with biological machinery in vitro when the encoded clutch selectively engages the engine with the rotor while external magnetic fields power the rotation.

    Research Briefing
  • A robust initialization protocol has been demonstrated for a four-qubit nuclear spin register in silicon. The protocol, driven electrically through electric-dipole spin resonance, enables high-fidelity qubit control and hence a route to a register-based quantum computer that exploits the exceptional coherence properties of atom qubits in silicon.

    Research Briefing
  • An electric dipole spin resonance protocol making use of hyperfine interaction enacts high-fidelity initialization of a four-qubit nuclear spin register in silicon. This protocol allows for high-fidelity qubit control and a path towards a register-based quantum computer using the exceptional coherence properties of donors in silicon.

    • J. Reiner
    • Y. Chung
    • M. Y. Simmons
    ArticleOpen Access
  • The nanospace confinement of a magnetic nanoparticle within a porous cage, coupled with an encodable DNA clutch interface, enables a remotely powered and controlled rotary nanomotor that is autoresponsive to its microenvironment.

    • Mouhong Lin
    • Jung-uk Lee
    • Jinwoo Cheon
    Article
  • An intelligent meta-imager can perform multi-channel convolutions to accelerate machine vision for incoherent light.

    • Zheng Huang
    • Hongwei Chen
    News & Views
  • The legal definition of a nanomaterial differs around the world, meaning that the same material may be classified as a nanomaterial, or not, depending on the country where it is classified. The first steps towards converging on an international definition are to recognize the differences between existing nanomaterial definitions and to agree on particle counting methods. Meanwhile, we propose a naming convention that indicates the key criteria of a specific definition of a nanomaterial.

    • Kirsten Rasmussen
    • Juan Riego Sintes
    • Hubert Rauscher
    Comment