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mRNA delivery through LNPs targeting specific organs holds great clinical potential, but it remains unclear how the structure of the lipidoids in the LNPs controls organ tropism. Here the authors direct in vivo delivery of siloxane-based LNPs via structural alteration of the ionizable structure of the constituting lipidoids.
A biased atomic force microscopy tip can write complex in-plane polar topologies in a model ferroelectric Pb0.6Sr0.4TiO3 by means of a smart scan path design. Hence, on-demand generation, reading and erasing of tunable topologies is possible.
Nano-masking of the surface of tumour-derived extracellular vesicles blocks their immune-evasive action. This improves their phagocytosis by dendritic cells, leading to maturation of T-cell action and culminating in undampened anti-tumour immunity.
Experiments on spin–orbit torque magnetization switching over seven orders of magnitude in current pulse duration unveil a transition from non-coherent to coherent magnetization reversal as pulse duration is reduced and a reduction of energy consumption in the picosecond regime by an order of magnitude.
This study introduces mechanochemistry-mediated colloidal liquid metals to enhance interface thermal transport in scalable electronic systems, offering an efficient cooling solution for thermal management in devices operating at kilowatt levels.
A sophisticated atomic force microscopy experiment enables a time-resolved tunnelling spectroscopy method that provides access to excited states of singles molecules. It quantifies the transition energies and can prepare a molecule in a specific excited state.
Current CAR T cell manufacturing falls short of mimicking immunological synapses. A new graphene oxide antigen-presenting platform (GO-APP) addresses this issue, improving CAR T cell production while eliminating the need for interleukin-2 supplementation.
A customized Ti-Nano resin is used to fabricate 3D photonic crystals with a complete bandgap in the visible spectrum through a nanoscale printing technique. The 3D printed and annealed titania photonic crystals show perfect reflectance within the wavelength range associated with this bandgap.
Acquired radiation resistance in residual tumours impedes the therapeutic outcome of re-irradiation. This study reports a novel radiosensitization strategy that targets cuproptosis to overcome resistance and enhance antitumour effects.
By inducing a transformation in a manganese-rich cation-disordered rocksalt, partially ordered spinels with nanomosaic domains of 3–7 nm in size can be obtained, which exhibit high energy density and rate capability at an average particle size of 3–5 µm.
Researchers demonstrate that cholesterol-enriched exosomes can deliver siRNA directly into cancer cells, bypassing normal cellular barriers and significantly enhancing gene silencing. This offers a more effective method for gene therapy applications.
A nanoscale printing method is developed to fabricate three-dimensional high-refractive index photonic crystals whose bandgap spans in the entire visible range.
Creating precise morphogen gradients for tissue engineering is challenging. Here the authors present mechanically tunable DNA hydrogel-based microbeads for light-controlled morphogen release in retinal organoids for better tissue mimicry.
This work employs nano- to microscale characterization to identify different structural change pathways associated with non-homogeneous reactions within the particles, and explores differences in the failure mechanisms of lithium-rich transition metal oxide materials at different current densities.
Orally administrable and glucose-responsive worm-like micelles have been developed to protect insulin in the gastrointestinal tract, enhance its intestinal absorption, accumulate in the liver and enable efficient and safe blood-glucose management.
