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Microcompartments with a temperature-responsive membrane are used to stably localize DNA-encoded files, which enables parallel, repeated polymerase-chain-reaction-based random access and DNA file sorting using fluorescent barcodes.
Atomically thin heterostructures function as optomemristors, which are used for biomimetic neural algorithms for performing winner-take-all tasks, such as competitive and cooperative learning.
An artificial ligament replacement is made from aligned carbon nanotubes formed into hierarchical helical fibres with nanometre and micrometre channels which are demonstrated for the replacement of anterior cruciate ligaments in both rabbit and ovine models, showing strong integration and functional recovery.
A floatable photocatalytic platform made from a porous elastomer–hydrogel nanocomposite has been developed for converting solar energy into hydrogen fuel. This platform enables efficient light delivery, a facile supply of reactant and rapid product separation to achieve high hydrogen-evolution rates. Large-scale and seawater experiments indicate the potential for scale-up and practical application.
Growth of molybdenum disulfide at 275 °C and monolithic integration of 2D transistors with silicon complementary metal oxide semiconductor circuits have been demonstrated.
Nanomedicines are complex drugs where components that have typically been regarded as excipients may now be considered part of the active ingredient. The distinction between the active ingredient and excipients for nanomedicines has important consequences for regulatory review and product development. The dissimilarity in the review of the recent ribonucleic acid (RNA)-based lipid nanoparticles highlights the need for further regulatory alignment on this topic.
Optimizing the retention of drug delivery nanocarriers for improved cancer therapy has the potential to improve clinical outcomes. Here the authors screen 20 renal-clearable zwitterionic cyclodextrin-based nanocarriers for optimized biodistribution and tumour retention, demonstrating application in colorectal cancer models.
Monolayer MoS2 is grown at the back end of the line of 200 mm silicon CMOS wafers at a temperature of <300 °C, and hybrid silicon CMOS/MoS2 circuits are demonstrated through heterogeneous integration.
This Review presents the most recent ferroelectric materials with wurtzite structure and emphasizes applications in memory and storage-based microelectronic hardware.
Floatable hydrogel nanocomposites, with facile intercalation of various photocatalysts, effectively produce hydrogen. The easily scalable nature of the nanocomposites demonstrates the practical application of this new type of photocatalytic platform.
Photonic Dirac metasurfaces with smooth trapping potentials guide optical modes endowed with pseudo-spin. Such potentials give rise to different radiative properties of modes of opposite pseudo-spin.
Intrinsic ferroelectricity in bilayer WTe2 can be used for electrical switching of the centred-rectangular moiré potential in WTe2/WSe2 heterostructures.
Wearable resistive sensors for biometrics and machine interfacing are often non-specific. Here the authors report on the creation of hierarchically resistive skins for monitoring physical or physiological activities around the throat which, with the use of neural networking, can be used to distinguish different activities.
Protease profiling of the tumour microenvironment using DNA-barcoded nanosensors and CRISPR amplification enables portable cancer diagnosis in preclinical models.
Single blood vessel analysis by artificial intelligence (AI) reveals heterogeneous vascular permeability among different tumour types, which is leveraged in rationally designing protein nanoparticle-based drug delivery systems to achieve active trans-endothelial permeability in tumours.
Inspired by the visual systems of agile insects, Chen et al. emulate their graded neurons using optoelectronic devices to realize bioinspired in-sensor motion perception and demonstrate high recognition accuracy with limited computational resources.
Operando synchrotron experiments reveal the Mn dissolution/redeposition dynamics in Mn-containing cathodes and offer insights into the regulation of Mn dissolution using ion-capturing polymers.
Systemic drug delivery to the bone marrow is limited, currently requiring high doses of drug, increasing the risk of side effects. Here, the authors report on the hitchhiking of drug nanoparticles in neutrophils using their natural homing to the bone marrow for targeted delivery, and demonstrate its application.