Browse Articles

Leveraging X-rays to induce prolonged luminescence (radio-afterglow) and radiodynamic effects from typically inorganic optical agents enables diagnosis and therapy at light-inaccessible tissue depths. Now, a cascade X-ray energy conversion approach is developed to increase the intrinsically low X-ray conversion efficiency of organic molecules for the construction of radio-afterglow nanoprobes for cancer theranostics.

Here, the authors present the design, molecular assembly and mechanistic insights into an organic, biomarker-activatable radiotheranostic nanoprobe for image-guided precision cancer radiotherapy with sensitivity up to a depth of 15 cm in thick tissues.

By using scanning tunnelling microscopy and spectroscopy, researchers observe layer-dependent electronic correlations in rhombohedral graphene multilayers at 77 K, revealing the layer-enhanced low-energy flat bands and interlayer interactions.

Single-molecule electrical detections clarify both productive and hidden degenerate pathways of ring-closing metathesis, and enable precise on-device synthesis of a single polymer with single-monomer-insertion-event resolution.

This study reports a fully integrated 128 × 8 optoelectronic memristor array with Si complementary metal–oxide–semiconductor circuits, featuring configurable multi-mode functionality. It demonstrates diversified in-sensor computing tasks and consumes 20 times less energy than GPUs.

The study presents a modular DNA origami-based single-molecule nanosensor that separates sensing from the signal output. It achieves high fluorescence resonance energy transfer contrast and enables tuning of the response window for improved sensor specificity, multiplexing and logic sensing.

This study presents the development of nanodrugs based on bacterial-derived outer membrane vesicles for targeted intervention in nerve–cancer crosstalk, which efficiently enhances pancreatic cancer chemotherapy.

Low-toxicity ZnSe–ZnS core–shell quantum dots show tunable and stable blue lasing in solution.

Singlet–triplet qubits implemented in a 2 × 4 germanium quantum dot array allow for a quantum circuit that generates and distributes entanglement across the array with a remote Bell state fidelity of 75(2)% between the first and last qubit.

Scanning tunnelling microscopy experiments enable the realization of artificially built topological quantum magnets with titanium atoms and graphene goblets.

From a single library of siloxane-based lipidoids, siloxane-incorporated lipid nanoparticles (SiLNPs) involving minor alterations in lipid chemistry yield tissue-specific mRNA delivery to the liver, lung, or spleen. Upon enhanced intracellular delivery, these SiLNPs show clinical promise for protein replacement therapies, regenerative medicine, and CRISPR–Cas-based gene editing applications.

This study presents P-selectin-targeting mimic ligand-coated NIR-II-interacting gold nanoparticle-based superclusters as in vivo contrast agents for enhanced imaging of intravascular inflammation in a rodent model using optical coherence tomography.

This Review presents a path to strategically overcoming extracellular vesicle heterogeneity and assay standardization, and offers solutions for realizing the clinical translation of extracellular vesicles for diagnostics and nanotherapeutics.

Phages are known as human-safe nanosized viruses that specifically infect bacteria. This work shows that non-lytic filamentous phages displaying a PD-L1-binding peptide and a melanoma-targeting peptide can efficiently target tumours and inhibit tumour growth by blocking the immune checkpoint.

Scanning probe microscopy experiments realize the alternating-exchange spin-1/2 Heisenberg model via magnetic nanographene chains. They control odd- to even-Haldane phase transitions and monitor spin–spin correlations and triplon dispersion.

This work introduces a reaction system that enables the in situ conversion of H₂O₂ generated by 2e⁻ ORR at the self-cleaning electrode surface into alkaline-earth metal peroxides. The solid oxidizer CaO₂ exhibits comparable efficiency to H₂O₂ for tetracycline degradation.

This study presents a flexible nanoparticle-based strategy for targeted protein degradation, simplifying the design process via intact nanoparticle trafficking routes and self-assembly. It provides knowledge for targeted nanomedicine design.

The amphiphilic silk fibroin is a natural surfactant. It influences interface interactions and enables wetting hydrophobic surfaces with aqueous solutions. This offers a sustainable route for fabricating water-processed nanodevices without prior surface modification.

Here the authors present a syntrophic vesicle system for selective transport of adenine nucleotides between ATP-producing and ATP-consuming nanoreactors. The platform can sustain synthetic cells, bionanoreactors and life-like entities with ATP.

This article presents a new method for coordinating iridium atoms with dimethylimidazole and cobalt–iron hydroxides. This enhances the oxygen evolution reaction and delivers high current densities with reduced precious metal use.