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Volume 8 Issue 10, October 2023

Freshwater metagenomic landscape

This image shows a lake in Canada, just one of the 308 lakes across the country that were sampled to generate a metagenomic compendium with the goal of assessing the breadth of bacterial metabolic potential and how it varies depending on regional land use changes.

See Garner et al.

Image: Candice Aulard, Université du Québec à Montréal. Cover Design: Valentina Monaco.


  • As more PhD students and postdoctoral fellows transition to professions outside academia, training programmes must prepare scientists for these alternative careers.



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Comment & Opinion

  • Thumbi Ndung’u reminisces about how far we have come in our fight against HIV-1, a pandemic virus that causes AIDS, and where we still need to go.

    • Thumbi Ndung’u
    Microbe Matters
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News & Views

  • Genomic epidemiology of the Yemen cholera outbreak reveals the genetic basis for emergence of multidrug resistance with implications for Vibrio cholerae surveillance and control.

    • Agila Kumari Pragasam
    • Veeraraghavan Balaji
    • Ankur Mutreja
    News & Views
  • Diverse marine bacteria exhibit a preference for either sugars or acids as carbon sources and this preference is predictable from genomic signatures.

    • Zeqian Li
    • Vaibhhav Sinha
    • Seppe Kuehn
    News & Views
  • Genetic and phenotypic changes that enable Pseudomonas to adapt to an animal host are identified. These traits are controlled by a universal signalling molecule and are shared by diverse strains.

    • Tory A. Hendry
    • Kelley A. Gallagher
    News & Views
  • Recovery and characterization of the wild-type pangolin coronavirus GD strain helps determine whether these viruses present risks for human transmission and an emerging threat to public health.

    • Woo-Jin Shin
    • Seokmin Kang
    • Jae U. Jung
    News & Views
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Research Briefings

  • Detection of poliovirus by cell culture and subsequent serotype identification via Sanger sequencing can be slow, delaying responses to emerging outbreaks. Direct virus detection using nested reverse transcription PCR and nanopore sequencing was prospectively validated in the Democratic Republic of the Congo and yielded accurate results in a fraction of the time.

    Research Briefing
  • Dietary fibre deprivation in mice increases the abundance of gut microbial mucin-degrading species, leads to barrier dysfunction and increases local type 2 inflammation. In a tractable human microbiota mouse model, the presence of Akkermansia muciniphila results in increased anti-commensal IgE and type 2 immune responses, worsening food allergy symptoms following sensitization.

    Research Briefing
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