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Volume 4 Issue 3, March 2019

Algal metabolic mapping goes viral

Combining the plaque assay with mass spectrometry imaging allowed metabolites produced during viral infection of the alga Emiliania huxleyi to be mapped at high spatiotemporal resolution, and identified a shift in lipid metabolism.

See Schleyer et al.

Image: Guy Schleyer and Yonghui Dong. Cover Design: Samantha Whitham.

Volume 4 Issue 3

Editorial

  • When accurate and thoughtfully presented, reporting of good science in the popular press should be celebrated and encouraged by researchers. In return, tabloid headline writers should dial down their hyperbolic rhetoric and avoid sensationalism when reporting scientific discoveries.

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  • Klebsiella pneumoniae isolated from patients with primary sclerosing cholangitis was found to cause intestinal barrier dysfunction resulting in T-helper-17-cell-mediated hepatobiliary injury, providing evidence for specific gut-derived, pore-forming pathogens as triggers for immune-mediated liver disease.

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  • Bacteria have previously been assumed to cope with environmental stress by tuning their total number of active ribosomes. Instead, a study in this issue of Nature Microbiology shows that from a heterogeneous pool of ribosomes, Vibrio vulnificus uses ribosomes with a particular ribosomal RNA variant to translate upregulated stress response mRNAs.

    • Kathrin Leppek
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  • Severe fever with thrombocytopenia virus is an emerging, highly lethal tick-borne pathogen with growing impact. In this issue of Nature Microbiology, two papers make major progress towards a better understanding of its so far incompletely understood mechanisms of virulence.

    • Jennifer Deborah Wuerth
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