Volume 4 Issue 11, November 2019

Volume 4 Issue 11

Aligning spirals

Magnetotactic bacteria must assemble magnetosomes into a linear chain that orients the cell along magnetic fields, yet how spiral bacteria with highly curved surfaces accomplish this is unclear. Here, MamY is shown to assemble into linear structures that serve as a scaffold for magnetosomes in magnetotactic spirilla.

See Toro-Nahuelpan, M. et al.

Image: Alexander Tokarev, Ella Maru Studio. Cover Design: Lauren Heslop.

Research

News & Views

  • News & Views |

    12,13-diHOME produced by the gut microbiome promotes an asthma-like immunophenotype in the lungs of a murine experimental model. Accordingly, the metabolite is elevated in neonates who developed asthma during childhood, potentially providing a biomarker for early risk prediction and a novel therapeutic target.

    • Christopher J. Stewart
  • News & Views |

    Some RNAs have to be made at maximal achievable rates, yet RNA polymerase encounters many obstacles that slow it down. A new study shows that a group of co-transcribing RNA polymerases communicate over long distances to work more efficiently than a solo enzyme.

    • Irina Artsimovitch

Research

  • Brief Communication |

    A statistical analysis of the associations between virus structure and virus transmission suggests that virus structures limit viral transmission routes and have implications for infection prophylaxis and gene therapy strategies.

    • Frederic D. Bushman
    • , Kevin McCormick
    •  & Scott Sherrill-Mix
  • Letter |

    A combination of secondary structure probing and RNA crosslinking sequencing approaches sheds lights on the RNA conformations and the intra- and intersegment interactions of the genome inside influenza A virions.

    • Bernadeta Dadonaite
    • , Brad Gilbertson
    • , Michael L. Knight
    • , Sanja Trifkovic
    • , Steven Rockman
    • , Alain Laederach
    • , Lorena E. Brown
    • , Ervin Fodor
    •  & David L. V. Bauer
  • Letter |

    Using metatranscriptomics of diatom-associated viruses and quantification of extracellular viruses in coastal water samples, the authors link silicon limitation to increased virus-induced mortality of diatoms, which could have implications for marine biogeochemical cycling.

    • Chana F. Kranzler
    • , Jeffrey W. Krause
    • , Mark A. Brzezinski
    • , Bethanie R. Edwards
    • , William P. Biggs
    • , Michael Maniscalco
    • , John P. McCrow
    • , Benjamin A. S. Van Mooy
    • , Kay D. Bidle
    • , Andrew E. Allen
    •  & Kimberlee Thamatrakoln
  • Letter |

    The cryo-electron microscopy structure of the ribosome from the microsporidium Vairimorpha necatrix reveals that, despite extreme genome compaction reducing the ribosomal RNA to a functionally conserved core, most ribosomal proteins are retained and adapt to form the minimized protein synthesis machinery in these eukaryotic parasites.

    • Jonas Barandun
    • , Mirjam Hunziker
    • , Charles R. Vossbrinck
    •  & Sebastian Klinge
  • Letter |

    The use of nanobodies that inhibit the self-assembly of the S-layer protein Sap from B. anthracis enabled the elucidation of the structure of this protein. The nanobodies also trigger disintegration of assembled S-layers and attenuate both bacterial growth and anthrax pathology in animal models of infection.

    • Antonella Fioravanti
    • , Filip Van Hauwermeiren
    • , Sander E. Van der Verren
    • , Wim Jonckheere
    • , Amanda Goncalves
    • , Els Pardon
    • , Jan Steyaert
    • , Henri De Greve
    • , Mohamed Lamkanfi
    •  & Han Remaut
  • Letter |

    Bacterial dimethylsulfoniopropionate (DMSP) production was recently demonstrated in surface oceans. Here the authors show that bacterial production is higher in sediment from coastal areas and the deep ocean, and identify an alternative pathway for its synthesis, indicating that coastal and marine sediments are important sources of this climate-relevant metabolite.

    • Beth T. Williams
    • , Kasha Cowles
    • , Ana Bermejo Martínez
    • , Andrew R. J. Curson
    • , Yanfen Zheng
    • , Jingli Liu
    • , Simone Newton-Payne
    • , Andrew J. Hind
    • , Chun-Yang Li
    • , Peter Paolo L. Rivera
    • , Ornella Carrión
    • , Ji Liu
    • , Lewis G. Spurgin
    • , Charles A. Brearley
    • , Brett Wagner Mackenzie
    • , Benjamin J. Pinchbeck
    • , Ming Peng
    • , Jennifer Pratscher
    • , Xiao-Hua Zhang
    • , Yu-Zhong Zhang
    • , J. Colin Murrell
    •  & Jonathan D. Todd
  • Letter |

    Here, the authors apply quantitative microbiome profiling to a metagenomics data set comprising patients with primary sclerosing cholangitis and/or inflammatory bowel disease and identify microbial taxa associated with inflammation or specific disease indicators, which were validated in an independent inflammatory bowel disease cohort.

    • Sara Vieira-Silva
    • , João Sabino
    • , Mireia Valles-Colomer
    • , Gwen Falony
    • , Gunter Kathagen
    • , Clara Caenepeel
    • , Isabelle Cleynen
    • , Schalk van der Merwe
    • , Séverine Vermeire
    •  & Jeroen Raes
  • Letter |

    Whole-genome resequencing and genome-wide association studies identify host candidate genes that influence the ability of the biocontrol agent Wolbachia to reduce dengue virus replication in its mosquito vector Aades aegypti.

    • Suzanne A. Ford
    • , Scott L. Allen
    • , Johanna R. Ohm
    • , Leah T. Sigle
    • , Aswathy Sebastian
    • , Istvan Albert
    • , Stephen F. Chenoweth
    •  & Elizabeth A. McGraw
  • Letter |

    The host protein Transportin-1 is a co-factor of HIV-1 infection, binding to the viral capsid to regulate the release of the viral genome and promoting its nuclear import.

    • Juliette Fernandez
    • , Anthony K. Machado
    • , Sébastien Lyonnais
    • , Célia Chamontin
    • , Kathleen Gärtner
    • , Thibaut Léger
    • , Corinne Henriquet
    • , Camille Garcia
    • , Débora M. Portilho
    • , Martine Pugnière
    • , Laurent Chaloin
    • , Delphine Muriaux
    • , Yohei Yamauchi
    • , Mickaël Blaise
    • , Sébastien Nisole
    •  & Nathalie J. Arhel
  • Article |

    Elevated concentrations of the lipid 12,13-diHOME in neonatal faeces is associated with childhood atopy and asthma. Here, the authors identify bacterial epoxide hydrolase genes that produce this lipid, are more abundant in the gut microbiota of neonates who develop atopy and/or asthma and are associated with diminished immune tolerance.

    • Sophia R. Levan
    • , Kelsey A. Stamnes
    • , Din L. Lin
    • , Ariane R. Panzer
    • , Elle Fukui
    • , Kathryn McCauley
    • , Kei E. Fujimura
    • , Michelle McKean
    • , Dennis R. Ownby
    • , Edward M. Zoratti
    • , Homer A. Boushey
    • , Michael D. Cabana
    • , Christine C. Johnson
    •  & Susan V. Lynch
  • Article |

    The ADP-ribosyltransferase PARP11 promotes ubiquitination and degradation of the interferon type I (IFN-I) receptor IFNAR1 by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP, thus suppressing the IFN-I-mediated antiviral responses both in vitro and in vivo.

    • Tingting Guo
    • , Yibo Zuo
    • , Liping Qian
    • , Jin Liu
    • , Yukang Yuan
    • , Kailin Xu
    • , Ying Miao
    • , Qian Feng
    • , Xiangjie Chen
    • , Lincong Jin
    • , Liting Zhang
    • , Chunsheng Dong
    • , Sidong Xiong
    •  & Hui Zheng
  • Article |

    Cryo-electron microscopy structures of the antifeeding prophage AFP from Serratia entomophila elucidate the interactions between the different components of this multiprotein contractile injection system and provide insights into its mechanism of contraction and toxin delivery.

    • Ambroise Desfosses
    • , Hariprasad Venugopal
    • , Tapan Joshi
    • , Jan Felix
    • , Matthew Jessop
    • , Hyengseop Jeong
    • , Jaekyung Hyun
    • , J. Bernard Heymann
    • , Mark R. H. Hurst
    • , Irina Gutsche
    •  & Alok K. Mitra
  • Article | | Open Access

    A machine learning approach was used to recover over 10,000 inovirus-like sequences from existing microbial genomes and metagenomes, consequently proposing the reclassification of the Inoviridae family to a viral order, and uncover the previously unrecognized diversity of these viruses across hosts and environments.

    • Simon Roux
    • , Mart Krupovic
    • , Rebecca A. Daly
    • , Adair L. Borges
    • , Stephen Nayfach
    • , Frederik Schulz
    • , Allison Sharrar
    • , Paula B. Matheus Carnevali
    • , Jan-Fang Cheng
    • , Natalia N. Ivanova
    • , Joseph Bondy-Denomy
    • , Kelly C. Wrighton
    • , Tanja Woyke
    • , Axel Visel
    • , Nikos C. Kyrpides
    •  & Emiley A. Eloe-Fadrosh
  • Article |

    Genomic and epidemiological analysis of carbapenem-resistant Klebsiella pneumoniae across Europe finds increased transmissibility of four clonal lineages, especially between hospitals within countries.

    • Sophia David
    • , Sandra Reuter
    • , Simon R. Harris
    • , Corinna Glasner
    • , Theresa Feltwell
    • , Silvia Argimon
    • , Khalil Abudahab
    • , Richard Goater
    • , Tommaso Giani
    • , Giulia Errico
    • , Marianne Aspbury
    • , Sara Sjunnebo
    • , Andi Koraqi
    • , Denada Lacej
    • , Petra Apfalter
    • , Rainer Hartl
    • , Youri Glupczynski
    • , Te-Din Huang
    • , Tanya Strateva
    • , Yuliya Marteva-Proevska
    • , Arjana Tambic Andrasevic
    • , Iva Butic
    • , Despo Pieridou-Bagatzouni
    • , Panagiota Maikanti-Charalampous
    • , Jaroslav Hrabak
    • , Helena Zemlickova
    • , Anette Hammerum
    • , Lotte Jakobsen
    • , Marina Ivanova
    • , Anastasia Pavelkovich
    • , Jari Jalava
    • , Monica Österblad
    • , Laurent Dortet
    • , Sophie Vaux
    • , Martin Kaase
    • , Sören G. Gatermann
    • , Alkiviadis Vatopoulos
    • , Kyriaki Tryfinopoulou
    • , Ákos Tóth
    • , Laura Jánvári
    • , Teck Wee Boo
    • , Elaine McGrath
    • , Yehuda Carmeli
    • , Amos Adler
    • , Annalisa Pantosti
    • , Monica Monaco
    • , Lul Raka
    • , Arsim Kurti
    • , Arta Balode
    • , Mara Saule
    • , Jolanta Miciuleviciene
    • , Aiste Mierauskaite
    • , Monique Perrin-Weniger
    • , Paul Reichert
    • , Nina Nestorova
    • , Sonia Debattista
    • , Gordana Mijovic
    • , Milena Lopicic
    • , Ørjan Samuelsen
    • , Bjørg Haldorsen
    • , Dorota Zabicka
    • , Elzbieta Literacka
    • , Manuela Caniça
    • , Vera Manageiro
    • , Ana Kaftandzieva
    • , Elena Trajkovska-Dokic
    • , Maria Damian
    • , Brandusa Lixandru
    • , Zora Jelesic
    • , Anika Trudic
    • , Milan Niks
    • , Eva Schreterova
    • , Mateja Pirs
    • , Tjasa Cerar
    • , Jesús Oteo
    • , Belén Aracil
    • , Christian Giske
    • , Karin Sjöström
    • , Deniz Gür
    • , Asli Cakar
    • , Neil Woodford
    • , Katie Hopkins
    • , Camilla Wiuff
    • , Derek J. Brown
    • , Edward J. Feil
    • , Gian Maria Rossolini
    • , David M. Aanensen
    •  & Hajo Grundmann
  • Article |

    In a mouse model of influenza virus infection, inflammatory dendritic cells are recruited to the infected trachea. Their activation through the C-type lectin receptor SIGN-R1 stimulates recruitment of natural killer cells and contributes to the control of viral replication.

    • Miguel Palomino-Segura
    • , Laurent Perez
    • , Yagmur Farsakoglu
    • , Tommaso Virgilio
    • , Irene Latino
    • , Rocco D’Antuono
    • , Nikolaos Chatziandreou
    • , Diego U. Pizzagalli
    • , Guojun Wang
    • , Adolfo García-Sastre
    • , Federica Sallusto
    • , Michael C. Carroll
    • , Olivier Neyrolles
    •  & Santiago F. Gonzalez
  • Article |

    Phylogeographical genomic analysis of Neisseria gonorrhoeae uncovers its recent emergence and current distribution into two distinct lineages that are differentially associated with antibiotic resistance and sexual networks.

    • Leonor Sánchez-Busó
    • , Daniel Golparian
    • , Jukka Corander
    • , Yonatan H. Grad
    • , Makoto Ohnishi
    • , Rebecca Flemming
    • , Julian Parkhill
    • , Stephen D. Bentley
    • , Magnus Unemo
    •  & Simon R. Harris
  • Article |

    Survival of epithelial club cells to influenza A virus infection depends on the ability of the DNA mismatch repair pathway to repair virus-induced oxidative damage and to promote the transcriptional induction of host antiviral genes.

    • Benjamin S. Chambers
    • , Brook E. Heaton
    • , Keiko Rausch
    • , Rebekah E. Dumm
    • , Jennifer R. Hamilton
    • , Sara Cherry
    •  & Nicholas S. Heaton
  • Article |

    Magnetotactic bacteria must assemble magnetosomes into a linear chain that orients the cell along magnetic fields, yet how spiral bacteria with highly curved surfaces accomplish this is unclear. Here, MamY is shown to assemble into linear structures that serve as a scaffold for magnetosomes in magnetotactic spirilla.

    • Mauricio Toro-Nahuelpan
    • , Giacomo Giacomelli
    • , Oliver Raschdorf
    • , Sarah Borg
    • , Jürgen M. Plitzko
    • , Marc Bramkamp
    • , Dirk Schüler
    •  & Frank-Dietrich Müller
  • Article |

    Small-angle X-ray scattering and crystal structures of the PA28 proteasome regulator from Plasmodium falciparum, combined with cryo-electron microscopy structures of the 20S proteasome in complex with these regulatory PA28 proteins and molecular dynamics simulations, elucidate the regulatory mechanisms of parasite proteasome degradation.

    • Stanley C. Xie
    • , Riley D. Metcalfe
    • , Eric Hanssen
    • , Tuo Yang
    • , David L. Gillett
    • , Andrew P. Leis
    • , Craig J. Morton
    • , Michael J. Kuiper
    • , Michael W. Parker
    • , Natalie J. Spillman
    • , Wilson Wong
    • , Christopher Tsu
    • , Lawrence R. Dick
    • , Michael D. W. Griffin
    •  & Leann Tilley
  • Article |

    Shigella flexneri aerobic respiration depletes mucosal oxygen in the colon to promote infection.

    • Jean-Yves Tinevez
    • , Ellen T. Arena
    • , Mark Anderson
    • , Giulia Nigro
    • , Louise Injarabian
    • , Antonin André
    • , Mariana Ferrari
    • , François-Xavier Campbell-Valois
    • , Anne Devin
    • , Spencer L. Shorte
    • , Philippe J. Sansonetti
    •  & Benoit S. Marteyn
  • Article |

    Cryo-EM imaging of the needle complex of the SPI-1 type III secretion system from Salmonella enterica serovar Typhimurium at different stages of complex assembly elucidates how needle assembly initiation is regulated and how the inner membrane and outer membrane rings of the complex interact, even with apparently incompatible symmetries.

    • Jinhong Hu
    • , Liam J. Worrall
    • , Marija Vuckovic
    • , Chuan Hong
    • , Wanyin Deng
    • , Claire E. Atkinson
    • , B. Brett Finlay
    • , Zhiheng Yu
    •  & Natalie C. J. Strynadka

Amendments & Corrections