Volume 3 Issue 9, September 2018

Volume 3 Issue 9

Engineering DNA eXPORT to soil bacteria

A donor strain (XPORT) that can transfer a miniature integrative and conjugative element from Bacillus subtilis (ICEBs1) enables DNA delivery into a broad range of bacterial strains isolated from human skin and gut, and soil.

See Brophy et al.

Image: Stocksolutions / Alamy Stock Photo. Cover Design: Samantha Whitham.

Editorial

  • Editorial |

    The second outbreak of Ebola virus disease in recent months in the Democratic Republic of the Congo will test local and international responses. Fortunately, the experience gained since the West African outbreak of 2013–2016 means that we are better prepared to meet the challenge than ever before.

Comment & Opinion

  • Comment |

    Looking back at how Zika virus emergence was handled during and after the 2015–2016 outbreak will be important for assessing how well multiple relevant stakeholders were integrated to mount a response, and can provide the groundwork to better cope with emerging infections in the future.

    • Marc Lecuit
    •  & Laurent Nguyen

News & Views

  • News & Views |

    Plasmodium parasites possess a unique PEXEL sorting pathway to deliver secretory proteins into the host cells in which they reside. A new study shows the existence of independent sorting/entry complexes to detect and deliver PEXEL proteins into the parasite endoplasmic reticulum.

    • Martin R. Pool
    •  & Ilaria Russo
  • News & Views |

    Genome-wide association studies and genetic analyses have identified a clinically prevalent alteration in the Mycobacterium tuberculosis genome that rewires bacterial propionate metabolism, conditionally reduces antibiotic killing without affecting minimum inhibitory concentrations, and may drive emergence of drug resistance.

    • Thomas Dick
    •  & Véronique Dartois
  • News & Views |

    An experimental evolution study shows that selection of a marine bacterium by warming favours adaptations that facilitate growth at low oxygen concentrations, linking evolutionary responses to these two key components of climate change in the ocean.

    • David A. Hutchins
  • News & Views |

    Studies in Drosophila reveal that the insect homologue of the stimulator of interferon genes (STING) exerts antiviral activity against Zika virus infection in the fly brain through the induction of autophagy, providing key insights into the possible evolutionary function of STING in antiviral defence.

    • Carolyn B. Coyne

Reviews

  • Review Article |

    This Review Article discusses the importance of considering known microbial processes to inform our understanding of the role of microbial communities in ecosystem processes, and a move away from approaches based solely on correlation analyses.

    • Ed K. Hall
    • , Emily S. Bernhardt
    • , Raven L. Bier
    • , Mark A. Bradford
    • , Claudia M. Boot
    • , James B. Cotner
    • , Paul A. del Giorgio
    • , Sarah E. Evans
    • , Emily B. Graham
    • , Stuart E. Jones
    • , Jay T. Lennon
    • , Kenneth J. Locey
    • , Diana Nemergut
    • , Brooke B. Osborne
    • , Jennifer D. Rocca
    • , Joshua P. Schimel
    • , Mark P. Waldrop
    •  & Matthew D. Wallenstein

Research

Amendments & Corrections