Volume 3 Issue 8, August 2018

Volume 3 Issue 8

Fungi feel Serratia’s edge

The type VI secretion system of Serratia marcescens can deliver effector proteins that target fungi, including pathogenic Candida species, via disruption of nutrient uptake, induction of autophagy or loss of plasma membrane potential.

See Trunk et al.

Image: Henrik Strahl and Katharina Trunk. Cover Design: Samantha Whitham.

Editorial

  • Editorial |

    The release of the World Health Organization’s Essential Diagnostics List highlights that diagnostics need to be a fundamental part of any effective public health system and the development of rapid, reliable and reasonably priced tests will be critical for tailoring appropriate treatments against infectious diseases.

Comment & Opinion

  • Comment |

    Pandemic influenza remains the single greatest threat to global heath security. Efforts to increase our preparedness, by improving predictions of viral emergence, spread and disease severity, by targeting reduced transmission and improved vaccination and by mitigating health impacts in low- and middle-income countries, should receive renewed urgency.

    • Peter Horby
  • Comment |

    A noticeable part of the microbiome literature, especially that working with low-biomass samples, is plagued by reagent contamination. Here we describe visual, statistical, methodical and ecological techniques to facilitate recognition of signals that represent contamination.

    • Marcus C. de Goffau
    • , Susanne Lager
    • , Susannah J. Salter
    • , Josef Wagner
    • , Andreas Kronbichler
    • , D. Stephen Charnock-Jones
    • , Sharon J. Peacock
    • , Gordon C. S. Smith
    •  & Julian Parkhill

News & Views

  • News & Views |

    Widespread use of antibiotics in animals either as growth promoters or for metaphylaxis may drive the spread of clinically relevant drug resistance genes and pathogens. New work uncovers drug resistance gene patterns from livestock across European farms and finds a correlation with agricultural antibiotic use.

    • Timothy R. Walsh
  • News & Views |

    What evolutionary strategies are used by parasites to flourish for long periods within their mammalian hosts? These are questions that have been addressed by Pinger et al. in a recent study that identifies variable O-glycosylation as a novel immune-evasion mechanism employed by African trypanosomes.

    • Mark Carrington
    •  & Matthew K. Higgins
  • News & Views |

    Commensal bacteria living on the skin can enhance the virulence of a skin pathogen, changing the way we think about the role of healthy skin microbiota in disease susceptibility.

    • Michelle Spoto
    •  & Julia Oh
  • News & Views |

    Bacteria use sophisticated translocation systems to manipulate or kill host cells and competing bacteria. A new study shows that bacteria also deliver anti-fungal effectors.

    • Sascha Brunke
    •  & Bernhard Hube
  • News & Views |

    It has been assumed that bacteria adapt to nutrient limitation by adjusting the number of ribosomes, no matter what they are being starved for. Instead, two recent studies show that Escherichia coli uses different approaches depending on whether its growth is limited by the availability of carbon, nitrogen or phosphate.

    • Katarzyna Potrykus
    •  & Michael Cashel

Reviews

  • Perspective |

    This Perspective argues that microbiome research needs to consider the different philosophical definitions of function to avoid confusion in the field, and uses the hologenome concept as an example.

    • Jonathan L. Klassen

Research

  • Letter | | Open Access

    The recovery of viral populations from peatland soils across a permafrost thaw gradient provides insights into soil viral diversity, their hosts and the potential impacts on carbon cycling in this environment.

    • Joanne B. Emerson
    • , Simon Roux
    • , Jennifer R. Brum
    • , Benjamin Bolduc
    • , Ben J. Woodcroft
    • , Ho Bin Jang
    • , Caitlin M. Singleton
    • , Lindsey M. Solden
    • , Adrian E. Naas
    • , Joel A. Boyd
    • , Suzanne B. Hodgkins
    • , Rachel M. Wilson
    • , Gareth Trubl
    • , Changsheng Li
    • , Steve Frolking
    • , Phillip B. Pope
    • , Kelly C. Wrighton
    • , Patrick M. Crill
    • , Jeffrey P. Chanton
    • , Scott R. Saleska
    • , Gene W. Tyson
    • , Virginia I. Rich
    •  & Matthew B. Sullivan
  • Letter |

    Skin commensals increase host susceptibility to Staphylococcus aureus infection through a liver macrophage and peptidoglycan-dependent axis.

    • Emma Boldock
    • , Bas G. J. Surewaard
    • , Daria Shamarina
    • , Manli Na
    • , Ying Fei
    • , Abukar Ali
    • , Alexander Williams
    • , Eric J. G. Pollitt
    • , Piotr Szkuta
    • , Paul Morris
    • , Tomasz K. Prajsnar
    • , Kathy D. McCoy
    • , Tao Jin
    • , David H. Dockrell
    • , Jos A. G. van Strijp
    • , Paul Kubes
    • , Stephen A. Renshaw
    •  & Simon J. Foster
  • Letter |

    Viral protein X from HIV-2/SIV targets the HUSH (TASOR, MPP8 and periphilin) complex for proteasomal degradation through recruitment of the DCAF1 ubiquitin ligase adaptor, enabling reactivation of latent proviruses.

    • Ghina Chougui
    • , Soundasse Munir-Matloob
    • , Roy Matkovic
    • , Michaël M Martin
    • , Marina Morel
    • , Hichem Lahouassa
    • , Marjorie Leduc
    • , Bertha Cecilia Ramirez
    • , Lucie Etienne
    •  & Florence Margottin-Goguet
  • Article |

    Metagenomic analyses of European pig and poultry farms show differing resistome profiles and an association with country-level antibiotic use.

    • Patrick Munk
    • , Berith Elkær Knudsen
    • , Oksana Lukjancenko
    • , Ana Sofia Ribeiro Duarte
    • , Liese Van Gompel
    • , Roosmarijn E. C. Luiken
    • , Lidwien A. M. Smit
    • , Heike Schmitt
    • , Alejandro Dorado Garcia
    • , Rasmus Borup Hansen
    • , Thomas Nordahl Petersen
    • , Alex Bossers
    • , Etienne Ruppé
    • , Haitske Graveland
    • , Alieda van Essen
    • , Bruno Gonzalez-Zorn
    • , Gabriel Moyano
    • , Pascal Sanders
    • , Claire Chauvin
    • , Julie David
    • , Antonio Battisti
    • , Andrea Caprioli
    • , Jeroen Dewulf
    • , Thomas Blaha
    • , Katharina Wadepohl
    • , Maximiliane Brandt
    • , Dariusz Wasyl
    • , Magdalena Skarzyńska
    • , Magdalena Zajac
    • , Hristo Daskalov
    • , Helmut W. Saatkamp
    • , Katharina D. C. Stärk
    • , Ole Lund
    • , Tine Hald
    • , Sünje Johanna Pamp
    • , Håkan Vigre
    • , Dick Heederik
    • , Jaap A. Wagenaar
    • , Dik Mevius
    •  & Frank M. Aarestrup
  • Article |

    Natural product biosynthesis gene clusters were identified in bacterial isolates from the Arabidopsis phyllosphere, including inhibitory products with antibiotic activity, demonstrating the potential of the phyllosphere as a resource for antibiotics.

    • Eric J. N. Helfrich
    • , Christine M. Vogel
    • , Reiko Ueoka
    • , Martin Schäfer
    • , Florian Ryffel
    • , Daniel B. Müller
    • , Silke Probst
    • , Markus Kreuzer
    • , Jörn Piel
    •  & Julia A. Vorholt
  • Article |

    The type VI secretion system of Serratia marcescens can deliver effector proteins that target fungi, including pathogenic Candida species, via disruption of nutrient uptake and metabolism or loss of plasma membrane potential.

    • Katharina Trunk
    • , Julien Peltier
    • , Yi-Chia Liu
    • , Brian D. Dill
    • , Louise Walker
    • , Neil A. R. Gow
    • , Michael J. R. Stark
    • , Janet Quinn
    • , Henrik Strahl
    • , Matthias Trost
    •  & Sarah J. Coulthurst
  • Article |

    Trypanosoma brucei parasites switch their variant surface glycoprotein (VSG) coats to escape immune recognition. The crystal structure of VSG3 reveals that additional modifications, such as O-glycosylation, further expand antigenic variation and potentiate immune evasion.

    • Jason Pinger
    • , Dragana Nešić
    • , Liaqat Ali
    • , Francisco Aresta-Branco
    • , Mirjana Lilic
    • , Shanin Chowdhury
    • , Hee-Sook Kim
    • , Joseph Verdi
    • , Jayne Raper
    • , Michael A. J. Ferguson
    • , F. Nina Papavasiliou
    •  & C. Erec Stebbins
  • Article |

    Different nutrient limitations slow down Escherichia coli translation via distinct mechanisms: P limitation leads to fewer ribosomes; N limitation reduces translation elongation via ribosome stalling; and C limitation is characterized by inactive ribosomes not bound to mRNA.

    • Sophia Hsin-Jung Li
    • , Zhiyuan Li
    • , Junyoung O. Park
    • , Christopher G. King
    • , Joshua D. Rabinowitz
    • , Ned S. Wingreen
    •  & Zemer Gitai
  • Article |

    A combination of genetics, microscopy and modelling identifies FrzX as a target of the Frz kinase that controls cell polarity in Myxococcus xanthus by serving as a gate that regulates the MglA–MglB–RomR relaxation oscillator.

    • Mathilde Guzzo
    • , Seán M. Murray
    • , Eugénie Martineau
    • , Sébastien Lhospice
    • , Grégory Baronian
    • , Laetitia My
    • , Yong Zhang
    • , Leon Espinosa
    • , Renaud Vincentelli
    • , Benjamin P. Bratton
    • , Joshua W. Shaevitz
    • , Virginie Molle
    • , Martin Howard
    •  & Tâm Mignot

Amendments & Corrections