Volume 3 Issue 6, June 2018

Volume 3 Issue 6

Plasmodium of the apes

Sequencing of gorilla- and chimpanzee-infecting Plasmodium species elucidates the evolutionary history of the Laverania subgenus and highlights features of the human-infecting Plasmodium falciparum species that enable parasite transmission in humans.

See Otto et al.

Image: USO / iStock / Getty Images Plus / Getty. Cover Design: Samantha Whitham.

Editorial

  • Editorial |

    Although the spotlight on CRISPR–Cas systems has shone on their immense potential as genome-editing tools, the field’s origins are rooted in the microbiology of phage–bacterium interactions. Furthering our understanding of these processes can uncover more systems and generate new reagents with revolutionary properties.

    Collection:

News & Views

  • News & Views |

    Comparative genomics of all known Laverania species that infect African great apes reveals interspecies gene transfer and convergent evolution, and identifies features of Plasmodium falciparum, the only human-infective species within this subgenus, that may have led to its speciation and spread globally.

    • Jane M. Carlton
  • News & Views |

    Genetic integration of a humanized chemotaxis receptor unexpectedly reveals that a widely expressed immune protein is targeted by Staphylococcus aureus Panton–Valentine leukocidin in a novel way, changing our fundamental understanding of toxin–receptor biology and host–pathogen interaction.

    • Brandon Lee
    •  & Juliane Bubeck Wardenburg
  • News & Views |

    The discovery and characterization of a phylum-level archaeal lineage in iron-rich hot springs—the Marsarchaeota—expands the phylogenetic depth and physiological diversity of aerobic archaea.

    • Andreas Teske
  • News & Views |

    Antibodies that potently neutralize highly diverse HIV-1 variants offer great potential for therapy and prevention. Passive administration of HIV-specific neutralizing antibodies genetically modified to have a long serum half-life has now been shown to confer long-lasting protection from infection in the rhesus macaque model.

    • Michelle Zanoni
    • , David Palesch
    •  & Guido Silvestri
  • News & Views |

    The small intestine microbiome has been revealed to play a critical role in nutritional signal transduction that enables the host to adapt its fat digestion and absorption capacities, suggesting that this microbial community may serve as a target to improve conditions of over- and undernutrition.

    • Michiel Kleerebezem

Reviews

  • Review Article |

    This Review Article details various methods that can be used for phylogeny-aware analyses of microbiome datasets, together with online tutorials, including the considerations and challenges of each method depending on the research question.

    • Alex D. Washburne
    • , James T. Morton
    • , Jon Sanders
    • , Daniel McDonald
    • , Qiyun Zhu
    • , Angela M. Oliverio
    •  & Rob Knight

Research

  • Letter |

    A murine diet high in microbiota-accessible carbohydrates (MACs) reduces Clostridium difficile colonization compared to a low-MAC diet, which is associated with changes in microbiota composition, short-chain fatty acid concentrations and inflammation.

    • Andrew J. Hryckowian
    • , William Van Treuren
    • , Samuel A. Smits
    • , Nicole M. Davis
    • , Jackson O. Gardner
    • , Donna M. Bouley
    •  & Justin L. Sonnenburg
  • Letter |

    Cross-neutralizing antibodies from human survivors of the West Africa Ebola outbreak target a conserved membrane-proximal region in the virus glycoprotein HR2–MPER, which can be used as an immunogen to elicit neutralizing antibodies in rabbits.

    • Andrew I. Flyak
    • , Natalia Kuzmina
    • , Charles D. Murin
    • , Christopher Bryan
    • , Edgar Davidson
    • , Pavlo Gilchuk
    • , Christopher P. Gulka
    • , Philipp A. Ilinykh
    • , Xiaoli Shen
    • , Kai Huang
    • , Palaniappan Ramanathan
    • , Hannah Turner
    • , Marnie L. Fusco
    • , Rebecca Lampley
    • , Nurgun Kose
    • , Hannah King
    • , Gopal Sapparapu
    • , Benjamin J. Doranz
    • , Thomas G. Ksiazek
    • , David W. Wright
    • , Erica Ollmann Saphire
    • , Andrew B. Ward
    • , Alexander Bukreyev
    •  & James E. Crowe Jr
  • Article |

    Sequencing of gorilla- and chimpanzee-infecting Plasmodium species elucidates the evolutionary history of the Laverania subgenus and highlights features of the human-infecting Plasmodium falciparum species that enable parasite transmission in humans.

    • Thomas D. Otto
    • , Aude Gilabert
    • , Thomas Crellen
    • , Ulrike Böhme
    • , Céline Arnathau
    • , Mandy Sanders
    • , Samuel O. Oyola
    • , Alain Prince Okouga
    • , Larson Boundenga
    • , Eric Willaume
    • , Barthélémy Ngoubangoye
    • , Nancy Diamella Moukodoum
    • , Christophe Paupy
    • , Patrick Durand
    • , Virginie Rougeron
    • , Benjamin Ollomo
    • , François Renaud
    • , Chris Newbold
    • , Matthew Berriman
    •  & Franck Prugnolle
  • Article |

    Quorum sensing (QS) is shown to control eukaryotic-specific behaviours. QS peptide Qsp1 plays a crucial role in the intercellular regulation of unisexual and bisexual reproduction in the ubiquitous fungal pathogen Cryptococcus neoformans.

    • Xiuyun Tian
    • , Guang-Jun He
    • , Pengjie Hu
    • , Lei Chen
    • , Changyu Tao
    • , Ying-Lu Cui
    • , Lan Shen
    • , Weixin Ke
    • , Haijiao Xu
    • , Youbao Zhao
    • , Qijiang Xu
    • , Fengyan Bai
    • , Bian Wu
    • , Ence Yang
    • , Xiaorong Lin
    •  & Linqi Wang
  • Article |

    Human CD45 serves as a receptor for the Staphylococcus aureus Panton–Valentine leukocidin (PVL) F-component LukF-PV and contributes to the species specificity behind PVL intoxication of human immune cells.

    • Angelino T. Tromp
    • , Michiel Van Gent
    • , Pauline Abrial
    • , Amandine Martin
    • , Joris P. Jansen
    • , Carla J. C. De Haas
    • , Kok P. M. Van Kessel
    • , Bart W. Bardoel
    • , Elisabeth Kruse
    • , Emilie Bourdonnay
    • , Michael Boettcher
    • , Michael T. McManus
    • , Christopher J. Day
    • , Michael P. Jennings
    • , Gérard Lina
    • , François Vandenesch
    • , Jos A. G. Van Strijp
    • , Robert Jan Lebbink
    • , Pieter-Jan A. Haas
    • , Thomas Henry
    •  & András N. Spaan
  • Article |

    Multidrug-resistant Escherichia coli have a high frequency of collateral sensitivity to antimicrobial peptides, which may arise from changes in lipopolysaccharide regulation.

    • Viktória Lázár
    • , Ana Martins
    • , Réka Spohn
    • , Lejla Daruka
    • , Gábor Grézal
    • , Gergely Fekete
    • , Mónika Számel
    • , Pramod K Jangir
    • , Bálint Kintses
    • , Bálint Csörgő
    • , Ákos Nyerges
    • , Ádám Györkei
    • , András Kincses
    • , András Dér
    • , Fruzsina R Walter
    • , Mária A Deli
    • , Edit Urbán
    • , Zsófia Hegedűs
    • , Gábor Olajos
    • , Orsolya Méhi
    • , Balázs Bálint
    • , István Nagy
    • , Tamás A Martinek
    • , Balázs Papp
    •  & Csaba Pál