Volume 2

  • No. 12 December 2017

    Eating on the fly

    Under nutritional limitation, modification of the Lactobacillus plantarum cell wall by D-alanylation of teichoic acids is important for host intestinal peptidase expression, and consequently growth of the Drosophila host.

    See Matos et al. 2, 1635–1647 (2017)

  • No. 11 November 2017

    Sleep no more

    Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant that is effective against T.b. gambiense infection in mice, suggesting a potential therapeutic for sleeping sickness.

    See Fontaine, F., Lecordier, L. et al. 2, 1500–1506 (2017)

  • No. 10 October 2017

    Viral solar systems

    Isolation of a cyanophage encoding photosystem I (PSI) and II (PSII) genes reveals that both PSI and PSII gene products are expressed during infection and inserted into host cyanobacterial membranes, resulting in enhanced electron flow. Phage carrying these PSI and PSII genes are abundant in marine environments.

    See Fridman et al. 2, 1350–1357 (2017)

  • No. 9 September 2017

    Going straight

    Growth of Escherichia coli in curved micro-channels that forced them to grow to a deformed shape, followed by release to allow a return to native form suggests that E. coli utilize mechanical stresses as cues for shape recovery.

    See Wong, F, et al. 2, 17115 (2017)

  • No. 8 August 2017

    A pinch of salt

    Methanonatronarchaeia are a distinct class-level lineage of extremely halophilic methanogens, which lack features of classical methanogenesis and have a high intracellular concentration of potassium, suggesting pottasium-based osmoprotection.

    See Sorokin et al. 2, 17081 (2017)

  • No. 7 July 2017

    Sending signals

    Linear polyubiquitin patches in the Salmonella Typhimurium ubiquitin coat, regulated by E3 ligase LUBAC and deubiquitinase OTULIN, serve as a platform to modulate xenophagy, NF-kB signalling, secretion of pro-inflammatory cytokines and bacterial proliferation. 

    See van Wijk et al. 2, 17066 (2017) and Noad et al. 2, 17063 (2017)

  • No. 6 June 2017

    Exit route  

    Single-particle analysis of cryo-electron microscopy structures elucidates the membrane complex of the mycobacterial ESX-5 type VII secretion system. This secretion pathway is used to deliver virulence factors from the bacterial cytoplasm into the host cell through a channel in the bacterial inner membrane. 

    See Beckham et al. 2, 17047 (2017)

  • No. 5 May 2017

    Cycle proficiency

    In the pathogenic blood stage of infection, Plasmodium falciparum cell-cycle progression is directed by the parasite-specific kinase CRK4. Without active CRK4, DNA replication is inhibited and the nuclei are deformed by spindle-like structures.

    See Ganter et al. 2, 17017 (2017)

  • No. 4 April 2017

    Stopping RSV in its tracks

    Crystal structures of two potent RSV antibodies in complex with the RSV fusion protein determine the molecular basis for neutralization of the virus, including a new antigenic site and the basis for cross-reactivity with human metapneumovirus.

    see Mousa, J. J. et al. 2, 16271 (2017) and Wen, X. et al. 2, 16272 (2017)

  • No. 3 March 2017

    Hot rod

    RodA is a glycosyltransferase found in Bacillus subtilis; bacterial extracts may be able to target the peptidoglycan polymerase pathway and serve as an antibiotic.

    See Emami et al. 2, 16253 (2017)


  • No. 2 February 2017

    Turning the tide on river blindness

    Characterization of the genomes of the parasite Onchocerca volvulus, the causative agent of river blindness, and its Wolbachia symbiont reveals potential therapeutic targets.

    See Cotton et al. 2, 16216 (2016)

  • No. 1 January 2017

    Imprinting on infection

    Previous infection with Escherichia coli epigenetically alters host epithelial cell maturation and COX-2-mediated inflammation to predispose mice for future recurrent infection.

    See O'Brien et al. 2, 16196 (2016)