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Volume 2 Issue 2, February 2017

Volume 2 Issue 2

Turning the tide on river blindness

Characterization of the genomes of the parasite Onchocerca volvulus, the causative agent of river blindness, and its Wolbachia symbiont reveals potential therapeutic targets.

See Cotton et al. 2, 16216 (2016)

Image: James CottonCover Design: Samantha Whitham


  • Editorial |

    Encouraging researchers to become activists and engage with the public to combat the rising tide of scientific mistrust is easier said than done. Harder still will be to better enable PhDs to thrive in careers away from science, in the public and private sectors, but doing so could bear substantial fruit in the long-term.

Comment & Opinion

  • Comment |

    Many species of Archaea, Bacteria and eukaryotes are polyploid in natural populations. The mixture of species with unknown but widely varying ploidy levels compromises marker-gene-based analyses of community structures, population dynamics and microbiomes.

    • Jörg Soppa

News & Views

  • News & Views |

    An effector protein secreted by the intracellular human pathogen Mycobacterium tuberculosis impairs antigen processing in targeted phagocytic cells, resulting in evasion from immune surveillance by a dedicated adaptive immune response.

    • Olivier Neyrolles
  • News & Views |

    Growth of Candida albicans on different host carbon sources reveals that the cell wall is a live organelle that can respond to alterations in the environment by masking a cell surface epitope to protect the fungal cell from the host immune response.

    • Jean-Paul Latgé
  • News & Views |

    Rhythmic colonization of gut bacteria on mucosal surfaces is promoted by time-dependent feeding, and is now shown to drive circadian expression of host genes that are involved in functions such as drug detoxification in the liver.

    • Liping Zhao
    • Chenhong Zhang


Amendments & Corrections


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