Volume 2 Issue 11, November 2017

Volume 2 Issue 11

Sleep no more

Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant that is effective against T.b. gambiense infection in mice, suggesting a potential therapeutic for sleeping sickness.

See Fontaine, F., Lecordier, L. et al. 2, 1500–1506 (2017)

Image: D. Perez-Morga and the Université Libre de Bruxelles, Cover Design: Karen Moore

Editorial

  • Editorial |

    An increased focus on identifying disease hotspots and pre-emptive intervention will be key to halting outbreaks before they become established, but political and economic obstacles cannot be ignored if ambitious new targets to reduce global cholera mortality tenfold are to be achieved.

News & Views

  • News & Views |

    The Uncultivated Bacteria and Archaea dataset is a foundational collection of 7,903 genomes from uncultivated microorganisms. It highlights how microbial diversity is readily recovered using current tools and existing metagenomic datasets to help piece together the tree of life.

    • Lindsey M. Solden
    •  & Kelly C. Wrighton
  • News & Views |

    Two studies identify circulating monocytes as the primary cellular target of Zika virus infection in human blood. Monocytes are an ideal target as they have the potential to be used as a Trojan horse to infiltrate immune-sheltered tissues, including placenta, testes and the brain, to spread Zika virus.

    • Kellie Ann Jurado
    •  & Akiko Iwasaki

Research

  • Letter |

    LysM, the lysis protein of the Escherichia coli levivirus M, represents a new ‘protein antibiotic’ that interferes with the synthesis of peptidoglycan by inhibiting lipid II flipping.

    • Karthik R. Chamakura
    • , Lok-To Sham
    • , Rebecca M. Davis
    • , Lorna Min
    • , Hongbaek Cho
    • , Natividad Ruiz
    • , Thomas G. Bernhardt
    •  & Ry Young
  • Letter |

    Infection of the alga Emiliania huxleyi with its virus EhV results in the increased release of extracellular vesicles that impact viral decay and infection, suggesting that EhV exploits these extracellular vesicles for efficient viral infection during algal blooms.

    • Daniella Schatz
    • , Shilo Rosenwasser
    • , Sergey Malitsky
    • , Sharon G. Wolf
    • , Ester Feldmesser
    •  & Assaf Vardi

    Collection:

  • Letter |

    Streptococcal para-amino benzoic acid enhances Porphyromonas gingivalis colonization while reducing virulence during polymicrobial oral infection.

    • Masae Kuboniwa
    • , John R. Houser
    • , Erik L. Hendrickson
    • , Qian Wang
    • , Samar A. Alghamdi
    • , Akito Sakanaka
    • , Daniel P. Miller
    • , Justin A. Hutcherson
    • , Tiansong Wang
    • , David A. C. Beck
    • , Marvin Whiteley
    • , Atsuo Amano
    • , Huizhi Wang
    • , Edward M. Marcotte
    • , Murray Hackett
    •  & Richard J. Lamont
  • Letter |

    Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant (rPpMUT) that is effective against T.b. gambiense infection in mice, suggesting that it may serve as a therapy against sleeping sickness.

    • Frédéric Fontaine
    • , Laurence Lecordier
    • , Gilles Vanwalleghem
    • , Pierrick Uzureau
    • , Nick Van Reet
    • , Martina Fontaine
    • , Patricia Tebabi
    • , Benoit Vanhollebeke
    • , Philippe Büscher
    • , David Pérez-Morga
    •  & Etienne Pays
  • Letter |

    The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.

    • Jing Wang
    • , Maximilian Brackmann
    • , Daniel Castaño-Díez
    • , Mikhail Kudryashev
    • , Kenneth N. Goldie
    • , Timm Maier
    • , Henning Stahlberg
    •  & Marek Basler
  • Article |

    CD81 is shown to interact with SAMHD1 and lead to its proteasomal degradation, thereby impacting dNTP availability and enhancing HIV-1 reverse transcription in primary human T cells.

    • Vera Rocha-Perugini
    • , Henar Suárez
    • , Susana Álvarez
    • , Soraya López-Martín
    • , Gina M. Lenzi
    • , Felipe Vences-Catalán
    • , Shoshana Levy
    • , Baek Kim
    • , María A. Muñoz-Fernández
    • , Francisco Sánchez-Madrid
    •  & Maria Yáñez-Mó
  • Article |

    The structures of a variant surface glycoprotein (VSG) from Trypanosoma brucei suggest that VSGs adopt different conformations to respond to obstacles present in the cell membrane, enabling them to maintain a protective coat at all times.

    • Thomas Bartossek
    • , Nicola G. Jones
    • , Christin Schäfer
    • , Mislav Cvitković
    • , Marius Glogger
    • , Helen R. Mott
    • , Jochen Kuper
    • , Martha Brennich
    • , Mark Carrington
    • , Ana-Sunčana Smith
    • , Susanne Fenz
    • , Caroline Kisker
    •  & Markus Engstler
  • Article | | open

    The recovery of 7,903 bacterial and archaeal metagenome-assembled genomes increases the phylogenetic diversity represented by public genome repositories and provides the first representatives from 20 candidate phyla.

    • Donovan H. Parks
    • , Christian Rinke
    • , Maria Chuvochina
    • , Pierre-Alain Chaumeil
    • , Ben J. Woodcroft
    • , Paul N. Evans
    • , Philip Hugenholtz
    •  & Gene W. Tyson
  • Article |

    TRIM23 is identified as an essential regulator of virus-induced autophagy that mediates restriction to several RNA and DNA viruses. K27-mediated ubiquitylation activates TRIM23 GTPase activity, triggering its relocalization and selective autophagy.

    • Konstantin M. J. Sparrer
    • , Sebastian Gableske
    • , Matthew A. Zurenski
    • , Zachary M. Parker
    • , Florian Full
    • , Gavin J. Baumgart
    • , Jiro Kato
    • , Gustavo Pacheco-Rodriguez
    • , Chengyu Liang
    • , Owen Pornillos
    • , Joel Moss
    • , Martha Vaughan
    •  & Michaela U. Gack
  • Article |

    Both African and epidemic strains of Zika virus are shown to target CD14+ monocytes, which are more susceptible in pregnant women, but African strains are associated with inflammatory responses, and epidemic strains with immunotolerance.

    • Suan-Sin Foo
    • , Weiqiang Chen
    • , Yen Chan
    • , James W. Bowman
    • , Lin-Chun Chang
    • , Younho Choi
    • , Ji Seung Yoo
    • , Jianning Ge
    • , Genhong Cheng
    • , Alexandre Bonnin
    • , Karin Nielsen-Saines
    • , Patrícia Brasil
    •  & Jae U. Jung

Amendments & Corrections