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Volume 1 Issue 6, June 2016

Volume 1 Issue 6

Reef microbialization

Analysis of 60 sites in three ocean basins suggests that overgrowth of fleshy algae on coral reefs supports higher microbial abundances dominated by copiotrophic, potentially pathogenic bacteria via the provision of dissolved inorganic carbon.

See Haas et al. 1, 16042 (2016)

Image: Yan Wei Lim                    Cover design: Karen Moore

Editorial

  • Editorial |

    Antimicrobials have been one of the biggest success stories in medical history, but the emergence of drug resistance is threatening our ability to successfully treat infections. New approaches, interdisciplinary frameworks and policies have an important role in preventing entry into a post-antimicrobial era.

Comment & Opinion

  • Comment |

    There are no antibiotic candidates simply waiting to be brought to market. Overcoming the scientific barriers to innovation will require research and coordination beyond anything that exists in academia, industry or government. We discuss a plan to accelerate the discovery of antibiotics and their transition into the clinic.

    • Carolyn K. Shore
    • Allan Coukell

Books & Arts

News & Views

  • News & Views |

    Human pressures on coral reefs are giving macroalgae a competitive advantage over reef-building corals. These algae support larger, and potentially pathogenic, microbial populations that are metabolically primed for less-efficient, yet faster, carbohydrate remineralization, perpetuating a vicious cycle of reef degradation.

    • Melissa Garren
  • News & Views |

    Several microbes produce proteases that cleave antibodies to evade immune recognition. Humans seem to have a receptor on myeloid cells that detects the presence of cleaved antibodies and activates innate immunity.

    • John Trowsdale
  • News & Views |

    Antibiotic therapy is a cornerstone of contemporary medicine. Resistance testing is the gold standard for selecting antibiotics, but in some cases they are surprisingly ineffective. A study now shows that pathogens can form a subset of cells which survive, and even continue to grow in the face of antibiotics.

    • Wolf-Dietrich Hardt
  • News & Views |

    The plant pathogenic fungus Fusarium oxysporum secretes an effector that is similar to a plant peptide hormone, underscoring the variety of mechanisms that plant pathogens have evolved to tamper with host physiology.

    • Sophien Kamoun
    • Cyril Zipfel

Research

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