Reviews & Analysis

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  • Three different studies identify Asgardarchaeota-linked virus genomes that share commonalities with both prokaryotic and eukaryotic viruses, yet they represent independent phylogenetic groups.

    • Tomas Alarcón-Schumacher
    • Susanne Erdmann
    News & Views
  • Well-replicated, ecologically realistic, long-term field experiments were conducted to test the effects of warming on soil microbial diversity. Warming significantly reduced the biodiversity of soil bacteria, fungi and protists by altering environmental selections and biotic interactions, potentially disrupting the functional processes of the soil ecosystem.

    Research Briefing
  • Modelling using metagenomic data has revealed partitioning of the ocean into discrete microbial genomic provinces, but climate change might restructure their global organization.

    • Justin R. Seymour
    News & Views
  • Large-scale CRISPRi chemical genetic screening in Mycobacterium tuberculosis identifies genes altering antibiotic potency and the repurposing of the antibiotic clarithromycin to treat tuberculosis in Southeast Asia.

    • Luiz Pedro Sório de Carvalho
    News & Views
  • Bacteria can be engineered to degrade antibiotics in the gut, maintaining colonization resistance against pathogenic bacteria and constraining the expansion of antibiotic resistance genes in mice.

    • Christine A. Olson
    • Peter J. Turnbaugh
    News & Views
  • Understanding the mechanisms and evolution of pathogenicity in fungi will bring us a step closer to reducing the annual toll of 1.6 million deaths from fungal disease.

    • Antonis Rokas
    Review Article
  • The gut microorganism Clostridium sporogenes can utilize amino-acid pairs to generate energy, and the resulting metabolites circulate in host plasma.

    • Alexander S. Little
    • Samuel H. Light
    News & Views
  • Dysbiosis of the gut microbiome is associated with increased susceptibility to recurrent urinary tract infection, defining a gut–bladder axis.

    • Mark A. Schembri
    • Nguyen Thi Khanh Nhu
    • Minh-Duy Phan
    News & Views
  • Bacterial taxa within the murine gut microbiota affect susceptibility to the widely used dextran sodium sulfate model of colitis.

    • Andrew J. Macpherson
    • Bahtiyar Yilmaz
    News & Views
  • “Everything is everywhere, but, the environment selects” — a hypothesis formulated by Lourens Baas Becking in 1934 — is used to frame research that analyses the sharing of Escherichia coli strains across humans, livestock and wildlife animals.

    • Willem van Schaik
    News & Views
  • Following bacterial infection, macrophages undergo metabolic changes that activate antibacterial responses. However, pathogens can exploit host immunometabolites as a signal for virulence induction. This Review examines the crosstalk between pathogens and macrophage immunometabolism.

    • Gili Rosenberg
    • Sebastian Riquelme
    • Roi Avraham
    Review Article
  • Sources of microbial metabolites in the surface ocean, their roles in ecology and biogeochemistry, and methods that can be used to analyse them are reviewed.

    • Mary Ann Moran
    • Elizabeth B. Kujawinski
    • Assaf Vardi
    Review Article
  • Metagenomics-based surveillance could transform global efforts to detect risks to human health within a One Health framework.

    • Karrie K. K. Ko
    • Kern Rei Chng
    • Niranjan Nagarajan
    Perspective
  • Metabolic changes in auxotrophs enrich the microbial community exometabolome and increase drug resistance.

    • Kevin R. Stindt
    • Megan N. McClean
    News & Views
  • Contractile injection systems are nanomachines used by bacteria to puncture target cell membranes, thereby mediating bacterial competition and infection of eukaryotic cells. Two studies shed light on the structural diversity of these molecular spearguns using advanced multiscale imaging techniques.

    • Ricardo D. Righetto
    • Benjamin D. Engel
    News & Views
  • This Review summarizes current knowledge on the vaginal microbiota and discusses how research can progress from association to mechanism to provide deeper insights into its role in health and disease.

    • Michael France
    • Madeline Alizadeh
    • Jacques Ravel
    Review Article