Latest Research

  • Article |

    APOBEC3G is shown to induce a potent, non-site-specific interference with reverse transcription through direct interaction with HIV-1 reverse transcriptase, and host DNA repair machinery is shown to cleave HIV-1 cDNA.

    • Darja Pollpeter
    • , Maddy Parsons
    • , Andrew E. Sobala
    • , Sashika Coxhead
    • , Rupert D. Lang
    • , Annie M. Bruns
    • , Stelios Papaioannou
    • , James M. McDonnell
    • , Luis Apolonia
    • , Jamil A. Chowdhury
    • , Curt M. Horvath
    •  & Michael H. Malim
  • Article |

    A machine-learning approach accounting for methodological differences in studies and complex interactions among taxa allows independent soil studies to be combined at the taxonomy-based level to assess bacterial community structure.

    • Kelly S. Ramirez
    • , Christopher G. Knight
    • , Mattias de Hollander
    • , Francis Q. Brearley
    • , Bede Constantinides
    • , Anne Cotton
    • , Si Creer
    • , Thomas W. Crowther
    • , John Davison
    • , Manuel Delgado-Baquerizo
    • , Ellen Dorrepaal
    • , David R. Elliott
    • , Graeme Fox
    • , Robert I. Griffiths
    • , Chris Hale
    • , Kyle Hartman
    • , Ashley Houlden
    • , David L. Jones
    • , Eveline J. Krab
    • , Fernando T. Maestre
    • , Krista L. McGuire
    • , Sylvain Monteux
    • , Caroline H. Orr
    • , Wim H. van der Putten
    • , Ian S. Roberts
    • , David A. Robinson
    • , Jennifer D. Rocca
    • , Jennifer Rowntree
    • , Klaus Schlaeppi
    • , Matthew Shepherd
    • , Brajesh K. Singh
    • , Angela L. Straathof
    • , Jennifer M. Bhatnagar
    • , Cécile Thion
    • , Marcel G. A. van der Heijden
    •  & Franciska T. de Vries
  • Letter |

    Zika virus infection of astrocytes in Ifnar –/– mice results in breakdown of the blood–brain barrier and CD8+ effector T-cell infiltration, which limits neuron infection but leads to Zika-virus-associated paralysis.

    • Kellie A. Jurado
    • , Laura J. Yockey
    • , Patrick W. Wong
    • , Sarah Lee
    • , Anita J. Huttner
    •  & Akiko Iwasaki
  • Letter |

    As certain phages can infect some Pseudomonas aeruginosa strains by binding to their pilins, the bacteria have evolved ways to modify these structures via the addition of O-antigen units or polymers of d-arabinofuranose to block phage attachment.

    • Hanjeong Harvey
    • , Joseph Bondy-Denomy
    • , Hélène Marquis
    • , Kristina M. Sztanko
    • , Alan R. Davidson
    •  & Lori L. Burrows
  • Article |

    How the oral epithelium discriminates pathogens from commensals is unclear. Ephrin A2 is now shown to bind exposed β-glucans on the surface of the fungal pathogen Candida albicans, which is required to mount a proinflammatory and antifungal response.

    • Marc Swidergall
    • , Norma V. Solis
    • , Michail S. Lionakis
    •  & Scott G. Filler
  • Letter |

    To evade autophagy-mediated killing when inside liver cells, the Plasmodium berghei protein UIS3 binds to a key regulator of the autophagy programme, the host protein LC3, and inhibits its interaction with downstream effectors.

    • Eliana Real
    • , Lénia Rodrigues
    • , Ghislain G. Cabal
    • , Francisco J. Enguita
    • , Liliana Mancio-Silva
    • , João Mello-Vieira
    • , Wandy Beatty
    • , Iset M. Vera
    • , Vanessa Zuzarte-Luís
    • , Tiago N. Figueira
    • , Gunnar R. Mair
    •  & Maria M. Mota
  • Article | | open

    Cultivation of a cellulolytic consortium reveals successional community dynamics and the presence of multidomain glycoside hydrolases assembled into stable complexes distinct from cellulosomes, which are produced by a potential pioneer population.

    • Sebastian Kolinko
    • , Yu-Wei Wu
    • , Firehiwot Tachea
    • , Evelyn Denzel
    • , Jennifer Hiras
    • , Raphael Gabriel
    • , Nora Bäcker
    • , Leanne Jade G. Chan
    • , Stephanie A. Eichorst
    • , Dario Frey
    • , Qiushi Chen
    • , Parastoo Azadi
    • , Paul D. Adams
    • , Todd R. Pray
    • , Deepti Tanjore
    • , Christopher J. Petzold
    • , John M. Gladden
    • , Blake A. Simmons
    •  & Steven W. Singer
  • Article |

    This study reports the viral and cellular N 6-methyladenosine (m6A) and N 6,2′-O-dimethyladenosine (m6Am) epitranscriptomes during KSHV latent and lytic infection, and shows that lytic replication induces dynamic epitranscriptome reprogramming of host pathways that control this process.

    • Brandon Tan
    • , Hui Liu
    • , Songyao Zhang
    • , Suzane Ramos da Silva
    • , Lin Zhang
    • , Jia Meng
    • , Xiaodong Cui
    • , Hongfeng Yuan
    • , Océane Sorel
    • , Shao-Wu Zhang
    • , Yufei Huang
    •  & Shou-Jiang Gao
  • Letter |

    The cell tropism of noroviruses in vivo remains unclear. Here, the dominant cellular targets during acute norovirus infection of immunocompetent mice are shown to be macrophages, dendritic cells, B cells and T cells in the GALT gut-associated lymphoid tissue.

    • Katrina R. Grau
    • , Alexa N. Roth
    • , Shu Zhu
    • , Abel Hernandez
    • , Natacha Colliou
    • , Bayli B. DiVita
    • , Drake T. Philip
    • , Cara Riffe
    • , Benoit Giasson
    • , Shannon M. Wallet
    • , Mansour Mohamadzadeh
    •  & Stephanie M. Karst
  • Article |

    Adaptation of the polony method allows numerical abundances of diverse viral groups to be quantified in environmental samples, and reveals that clade B T7-like cyanophages that carry the <Emphasis Type=”Italic”>psbA</Emphasis> gene are more abundant in the Red Sea than clade A phages.

    • Nava Baran
    • , Svetlana Goldin
    • , Ilia Maidanik
    •  & Debbie Lindell
  • Article |

    A CRISPR–Cas9-based gene drive array platform is developed and combined with mating-competent Candida albicans haploids to generate homozygous double-deletion mutants, transforming our ability to do genetic interaction analyses in fungi.

    • Rebecca S. Shapiro
    • , Alejandro Chavez
    • , Caroline B. M. Porter
    • , Meagan Hamblin
    • , Christian S. Kaas
    • , James E. DiCarlo
    • , Guisheng Zeng
    • , Xiaoli Xu
    • , Alexey V. Revtovich
    • , Natalia V. Kirienko
    • , Yue Wang
    • , George M. Church
    •  & James J. Collins
  • Letter |

    Using transcriptome data from marine subsurface sediments, expressed microbial enzymes are shown to be potential targets for secretion by Bacteria, Archaea and Fungi, providing insights into nutrient cycling in the subsurface environment.

    • William D. Orsi
    • , Thomas A. Richards
    •  & Warren R. Francis
  • Letter |

    The crystal structure of MlaA, coupled with simulations of its interaction with phospholipids, elucidates how this outer membrane lipoprotein acts as a phospholipid translocation channel to maintain the asymmetric composition of the outer membrane.

    • Javier Abellón-Ruiz
    • , Shreyas S. Kaptan
    • , Arnaud Baslé
    • , Beatrice Claudi
    • , Dirk Bumann
    • , Ulrich Kleinekathöfer
    •  & Bert van den Berg
  • Article |

    Bacillus subtilis cells are able to sense self-produced autoinducers, which gives rise to stronger quorum-sensing-mediated responses, in a process that can influence the generation of persisters during antibiotic treatment.

    • Tasneem Bareia
    • , Shaul Pollak
    •  & Avigdor Eldar
  • Letter |

    Structural illumination of host glycan interaction in the evolution and host adaptation of the Salmonella typhoid toxin.

    • Xiang Gao
    • , Lingquan Deng
    • , Gabrielle Stack
    • , Hai Yu
    • , Xi Chen
    • , Yuko Naito-Matsui
    • , Ajit Varki
    •  & Jorge E. Galán
  • Article |

    Comparative genomics and high-resolution mass spectrometry reveal the biosynthetic gene clusters, and vast chemical diversity of natural products that they encode, in Photorhabdus and Xenorhabdus, bacteria that interact with hosts as symbionts and entomopathogens.

    • Nicholas J. Tobias
    • , Hendrik Wolff
    • , Bardya Djahanschiri
    • , Florian Grundmann
    • , Max Kronenwerth
    • , Yi-Ming Shi
    • , Svenja Simonyi
    • , Peter Grün
    • , David Shapiro-Ilan
    • , Sacha J. Pidot
    • , Timothy P. Stinear
    • , Ingo Ebersberger
    •  & Helge B. Bode
  • Article |

    Under nutritional limitation, modification of the Lactobacillus plantarum cell wall by d-alanylation of teichoic acids is important for host intestinal peptidase expression and consequently growth of the Drosophila host, providing further insights into host–commensal interactions.

    • Renata C. Matos
    • , Martin Schwarzer
    • , Hugo Gervais
    • , Pascal Courtin
    • , Pauline Joncour
    • , Benjamin Gillet
    • , Dali Ma
    • , Anne-Laure Bulteau
    • , Maria Elena Martino
    • , Sandrine Hughes
    • , Marie-Pierre Chapot-Chartier
    •  & François Leulier
  • Article |

    An atomic model for a type 2 secretion system pseudopilus from Klebsiella oxytoca reveals a comprehensive network of inter-subunit contacts while mutational and functional analyses highlight the role of calcium in PulG folding and stability.

    • Aracelys López-Castilla
    • , Jenny-Lee Thomassin
    • , Benjamin Bardiaux
    • , Weili Zheng
    • , Mangayarkarasi Nivaskumar
    • , Xiong Yu
    • , Michael Nilges
    • , Edward H. Egelman
    • , Nadia Izadi-Pruneyre
    •  & Olivera Francetic
  • Article |

    Fluorescent d-amino acid incorporation reveals host–prey cell wall modification during Bdellovibrio bacteriovorus predation including pore formation and l,d-transpeptidase-mediated prey strengthening.

    • Erkin Kuru
    • , Carey Lambert
    • , Jonathan Rittichier
    • , Rob Till
    • , Adrien Ducret
    • , Adeline Derouaux
    • , Joe Gray
    • , Jacob Biboy
    • , Waldemar Vollmer
    • , Michael VanNieuwenhze
    • , Yves V. Brun
    •  & R. Elizabeth Sockett