Research articles

Infection by Trypanosoma brucei activates ATGL-dependent lipolysis in adipocytes, which reduces tissue parasite load and increases host survival.

Genomic fitness profiling of Acinetobacter baumannii treated with ten clinically relevant biocides using TraDIS reveals a common mechanism of action through dissipation of membrane potential that can promote antibiotic tolerance.

Intravenous administration of the BCG vaccine protects non-human primates with pre-existing SIV infection from tuberculosis.

Variation in infection dynamics and host cell sensing kinetics shape human antiviral response.

Computational, experimental and structural analyses reveal an abundant, nucleoid-associated histone and an alternative mode for DNA binding in vitro in the bacterium Bdellovibrio bacteriovorus.

Analysis of metagenomes from across the globe reveals the spectrum of soil microbial functional diversity based on community aggregated traits.

Genomic epidemiology of Vibrio cholerae isolates recovered between 2016 and 2019 during the Yemen cholera outbreak reveals acquisition of multidrug resistance and patterns of plasmid transmission between endemic and epidemic lineages.

Antibacterial combinations that are potent against Gram-positive bacteria are identified using an automated high-throughput screen.

Culture-independent CRISPR spacer screens enable the discovery of hundreds of viruses and mobile genetic elements infecting all known methanogenic lineages.

Pangolin coronavirus GD has reduced replication and transmission fitness compared with SARS-CoV-2, and therapies approved for SARS-CoV-2 are effective against this virus.

Electron cryo-microscopy revealed that ribosomes from microsporidian parasites were in a hibernating state, whereby the ribosomes form inactive pairs.

The gut commensal Akkermansia muciniphila regulates food allergy symptoms in a diet-dependent manner in mice.

Identification of divisome proteins related to human gephyrin and its membrane receptor in non-model Gram positive Corynebacteriales could provide new antibiotic targets for important pathogens including M. tuberculosis and C. diptheriae.

M3-seq uses combinatorial indexing alongside post hoc rRNA depletion in a single-cell RNA sequencing approach that reveals bacterial heterogeneity and rare populations during antibiotic stress and phage infection, as well as bet-hedging responses during growth.

Carbon catabolism of heterotrophic bacteria can be described using a simple general principle, which is their preference for either glycolytic (sugars) or gluconeogenic (amino and organic acids) carbon sources. This is reflected in their genomes via pathway abundances and GC content.

The bacterial second messenger c-di-GMP is important for host association of microbes in C. elegans and beyond.

The Parkinson’s disease-associated leucine-rich repeat kinase 2 acts as a protein scaffold promoting mitochondria–Salmonella-containing vacuole tether formation and itaconate delivery to provide cell-intrinsic defence in Salmonella-infected macrophages.

Plasmodium falciparum candidate artemisinin partial-resistance Kelch13 622I mutation co-occurs with pfhrp2/3 deletions in Ethiopia.

Trehalose polyphleates are surface-exposed glycolipids that are required for successful infection by phages BPs and Muddy when infecting Mycobacterium abscessus and M. smegmatis.

Prospective validation in the Democratic Republic of the Congo shows that implementation of nested polymerase chain reaction and nanopore sequencing is feasible in a national poliovirus laboratory