Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Analysis of four Wolbachia strains that have co-diverged with their host lineage for ∼2 million years suggests a ∼200 Ma origin for supergroups A and B and reveals evidence for a recent lateral transfer of a complete biotic synthesis operon.
Marine microorganisms inhabit diverse environments and interact over different spatial and temporal scales. To fully understand how these interactions shape genome structures, cellular responses, lifestyles, community ecology and biogeochemical cycles, integration of diverse approaches and data is essential.
As we enter 2017, Nature Microbiology completes its first year as a journal dedicated to publishing work of the highest quality from across the field. And what a year it has been. We take this opportunity to mark up the report card and check on our progress.
The biologically active form of vitamin B1 is not required by Borrelia burgdorferi, the bacterium that causes Lyme disease, challenging the paradigm that this vitamin is essential for all living organisms.
Type VII protein secretion systems are most widely associated with virulence in bacterial pathogens. A new study reveals a type VII system-secreted nuclease toxin that specifically affects clonally unrelated strains, thus placing type VII secretion directly into the fray of microbial competition.
Bacterial infection of the bladder can lead to mucosal remodelling and increased predisposition to recurrent infection, changing the way we view host susceptibility and providing new opportunities to develop novel therapeutics.
The symbiosis between UCYN-A and haptophyte picoplankton plays a major role in oceanic nitrogen cycling. Though it bears some resemblance to freshwater examples, making it an interesting marine model, UCYN-A diversity means that many questions remain.
To replicate in Huh7 hepatoma cells, HCV must acquire mutations that prevent PI4KA over-activation. PI4KA-specific inhibitors promote replication of unadapted viral isolates and allow replication of patient-derived virus in cell culture.
Genomic analysis suggests pandemic Vibrio cholerae probably originated from a subset of environmental strains with alleles compatible with host colonization.
Viability polymerase chain reaction based on the photoreactive DNA-intercalating dye propidium monoazide revealed that on average 40% of prokaryotic and fungal DNA in soil is extracellular, or from cells no longer intact, confounding estimates of richness and taxon relative abundance.
While stimulation of TLR4 with LPS leads to an increase in glycolysis and a decrease in oxidative phosphorylation, complex microbial stimuli and the TLR2 ligand P3C induce upregulation of both glycolysis and oxidative phosphorylation.
Legionella pneumophila effector LepB harbours a cryptic lipid kinase domain that produces phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2). Successive LepB kinase and SidF phosphatase activities are needed for the generation of PtdIns4P on the Legionella-containing vacuole.
In response to lactate exposure, Candida albicans induces masking of β-glucan, a key PAMP, via a signalling pathway involving the Gpr1 receptor and Crz1 transcription factor.
Antibiotics reduce the fraction of active ribosomes rather than slow translational elongation, a process also observed during E. coli adaptation to slow-growth conditions.
An effector protein secreted by the intracellular human pathogen Mycobacterium tuberculosis impairs antigen processing in targeted phagocytic cells, resulting in evasion from immune surveillance by a dedicated adaptive immune response.