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  • Rapid experimental evolution and targeted genetic engineering of Escherichia coli in a stinkbug host reveals that a single mutation can produce a host-beneficial symbiosis.

    • Martin Kaltenpoth
    News & Views
  • Identification and analysis of mutator strains in the human fungal pathogen Cryptococcus neoformans show that natural loss of RNA interference triggers massive accumulation of Cnl1 retroelements at subtelomeric regions.

    • Manning Y. Huang
    • Hiten D. Madhani
    News & Views
  • Phylogeny estimation of newly discovered aquatic copiotrophic Rickettsiales indicates evolution of host dependency from extracellular species and the origin of mitochondria from an unknown proteobacterial lineage.

    • Victoria I. Verhoeve
    • Joseph J. Gillespie
    News & Views
  • Chikungunya virion assembly is elucidated using cryo-electron tomography to reveal how antibodies protect hosts by blocking virion release from virus-infected cells.

    • Julie M. Fox
    • Theodore C. Pierson
    News & Views
  • Vaccine immunity against SARS-CoV-2 wanes over time and is generally lower in the older population. Recent studies show that booster doses may increase neutralizing antibodies in older adults and protect against emerging variants, including Omicron.

    • Sara Hägg
    • Dorota Religa
    News & Views
  • Enteric Salmonella not only activates the ILC3–IL-22 axis upon infection to provide a competitive advantage over resident microbiota but also invades ILC3s and induces inflammatory cell death, thus limiting infection.

    • Ann M. Joseph
    • Gregory F. Sonnenberg
    News & Views
  • Three different studies identify Asgardarchaeota-linked virus genomes that share commonalities with both prokaryotic and eukaryotic viruses, yet they represent independent phylogenetic groups.

    • Tomas Alarcón-Schumacher
    • Susanne Erdmann
    News & Views
  • Modelling using metagenomic data has revealed partitioning of the ocean into discrete microbial genomic provinces, but climate change might restructure their global organization.

    • Justin R. Seymour
    News & Views
  • Large-scale CRISPRi chemical genetic screening in Mycobacterium tuberculosis identifies genes altering antibiotic potency and the repurposing of the antibiotic clarithromycin to treat tuberculosis in Southeast Asia.

    • Luiz Pedro Sório de Carvalho
    News & Views
  • Bacteria can be engineered to degrade antibiotics in the gut, maintaining colonization resistance against pathogenic bacteria and constraining the expansion of antibiotic resistance genes in mice.

    • Christine A. Olson
    • Peter J. Turnbaugh
    News & Views
  • The gut microorganism Clostridium sporogenes can utilize amino-acid pairs to generate energy, and the resulting metabolites circulate in host plasma.

    • Alexander S. Little
    • Samuel H. Light
    News & Views
  • Dysbiosis of the gut microbiome is associated with increased susceptibility to recurrent urinary tract infection, defining a gut–bladder axis.

    • Mark A. Schembri
    • Nguyen Thi Khanh Nhu
    • Minh-Duy Phan
    News & Views
  • Bacterial taxa within the murine gut microbiota affect susceptibility to the widely used dextran sodium sulfate model of colitis.

    • Andrew J. Macpherson
    • Bahtiyar Yilmaz
    News & Views
  • “Everything is everywhere, but, the environment selects” — a hypothesis formulated by Lourens Baas Becking in 1934 — is used to frame research that analyses the sharing of Escherichia coli strains across humans, livestock and wildlife animals.

    • Willem van Schaik
    News & Views
  • Metabolic changes in auxotrophs enrich the microbial community exometabolome and increase drug resistance.

    • Kevin R. Stindt
    • Megan N. McClean
    News & Views
  • Contractile injection systems are nanomachines used by bacteria to puncture target cell membranes, thereby mediating bacterial competition and infection of eukaryotic cells. Two studies shed light on the structural diversity of these molecular spearguns using advanced multiscale imaging techniques.

    • Ricardo D. Righetto
    • Benjamin D. Engel
    News & Views
  • A potential new therapeutic approach that targets the unique nutrient requirements of Lactobacillus iners to improve bacterial vaginosis treatment outcomes is described.

    • Lindi Masson
    • Andrea G. Abrahams
    • Monalisa T. Manhanzva
    News & Views
  • Infection by Mycobacterium tuberculosis (Mtb) induces remodelling of the host-cell transcriptome, which is mediated by epigenetic mechanisms. Histone acetylation of KCNJ15 stimulates transcription and the activation of genes implicated in apoptosis to promote Mtb clearance.

    • Melanie A. Carless
    • Larry S. Schlesinger
    News & Views